Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1044410..1045030 Replicon chromosome
Accession NZ_CP040256
Organism Enterobacter ludwigii strain JP6

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag ELJP6_RS04915 Protein ID WP_014168902.1
Coordinates 1044410..1044628 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag ELJP6_RS04920 Protein ID WP_020885187.1
Coordinates 1044656..1045030 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELJP6_RS04885 1040420..1040680 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
ELJP6_RS04890 1040683..1040823 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
ELJP6_RS04895 1040820..1041530 - 711 WP_138013559.1 GNAT family N-acetyltransferase -
ELJP6_RS04900 1041631..1043092 + 1462 Protein_944 PLP-dependent aminotransferase family protein -
ELJP6_RS04905 1043064..1043531 - 468 WP_020885189.1 extracytoplasmic function sigma factor YlaC -
ELJP6_RS04910 1043649..1044200 - 552 WP_020885188.1 maltose O-acetyltransferase -
ELJP6_RS04915 1044410..1044628 - 219 WP_014168902.1 hemolysin expression modulator Hha Toxin
ELJP6_RS04920 1044656..1045030 - 375 WP_020885187.1 Hha toxicity modulator TomB Antitoxin
ELJP6_RS04925 1045542..1048688 - 3147 WP_014168904.1 multidrug efflux RND transporter permease subunit -
ELJP6_RS04930 1048711..1049904 - 1194 WP_020885186.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T125200 WP_014168902.1 NZ_CP040256:c1044628-1044410 [Enterobacter ludwigii]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

>T125200 NZ_CP040256:c1044628-1044410 [Enterobacter ludwigii]
ATGTCTGAAAAACCACTCACAAAAATCGATTATTTGATGCGTTTGCGACGCTGCCAGTCAATAGACACGCTTGAACGTGT
AATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCGGCTGACCACCGTCTTGCAGAAC
TGACCATGAATAAGCTGTATGACAAAATCCCAACGTCCGTGTGGAGATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT125200 WP_020885187.1 NZ_CP040256:c1045030-1044656 [Enterobacter ludwigii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp

>AT125200 NZ_CP040256:c1045030-1044656 [Enterobacter ludwigii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTAAACGAGTTGATCGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGATGAATACCTG
GATGACACCTTTATGTTGTTCAGCAGCTACGGCATTAATGCGCAAGATTTGCAGAAATGGCGTAAATCGGGCAACCGACT
ATTTCGTTGCTTCATCAACGTGAGCAGAGCTAACCCCGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BM33

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BX74

References