Detailed information of TA system TA125199

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 479768..480284
• Replicon: chromosome
• Accession: NZ_CP040256
• Organism: Enterobacter ludwigii strain JP6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ELJP6_RS02275
• Protein ID: WP_138013445.1
• Coordinates: 480000..480284 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A839BTQ9
• Locus tag: ELJP6_RS02270
• Protein ID: WP_020885404.1
• Coordinates: 479768..480010 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELJP6_RS02255	475765..476505	+	741	WP_134179347.1	KDGP aldolase family protein	-
ELJP6_RS02260	476624..477760	+	1137	WP_134179346.1	lactonase family protein	-
ELJP6_RS02265	477780..479690	+	1911	WP_138013444.1	BglG family transcription antiterminator	-
ELJP6_RS02270	479768..480010	+	243	WP_020885404.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ELJP6_RS02275	480000..480284	+	285	WP_138013445.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ELJP6_RS02280	480288..480752	-	465	WP_138013446.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
ELJP6_RS02285	480891..483029	-	2139	WP_020885401.1	anaerobic ribonucleoside-triphosphate reductase	-
ELJP6_RS02290	483397..483969	-	573	WP_138013447.1	PTS sugar transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10784.56 Da
• Isoelectric Point: 10.4181

>T125199 WP_138013445.1 NZ_CP040256:480000-480284 [Enterobacter ludwigii]
MTYELVFDPRAFKEWARLGDTVKNQFKKKLANVLVNPRVESARLHGLPDCDKIKLRSQGYRLVYQVQDNVVTVCVIAIGK
REKSAVSHDANKRL

Nucleotide

• Length: 285 bp

>T125199 NZ_CP040256:480000-480284 [Enterobacter ludwigii]
ATGACTTATGAACTCGTATTTGATCCGAGGGCGTTCAAGGAGTGGGCCAGGCTGGGTGATACCGTAAAAAATCAGTTTAA
GAAGAAGCTTGCGAACGTGTTGGTGAACCCCAGGGTTGAATCGGCTCGCCTGCATGGCCTGCCTGATTGCGACAAGATAA
AACTCAGATCCCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAACGTTGTGACGGTGTGTGTTATTGCTATCGGTAAG
AGAGAGAAATCAGCCGTTTCTCATGACGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9085.49 Da
• Isoelectric Point: 5.1088

>AT125199 WP_020885404.1 NZ_CP040256:479768-480010 [Enterobacter ludwigii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDELIQTVRERLANPQKGIKVRLDDL

Nucleotide

• Length: 243 bp

>AT125199 NZ_CP040256:479768-480010 [Enterobacter ludwigii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTTGAAAAACTCAATATCACGCC
AACGGAAGCCGTTCGGTTACTGTTTCAGTACGTTGCGGAGACGGGGCGTATGCCGGTGAAAACGGTCACTGTCAGCGACA
GTGAAGATGAACTCATACAGACAGTCCGGGAGCGGCTGGCTAATCCGCAAAAAGGAATTAAGGTTAGGCTGGATGACTTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A839BTQ9