Detailed information of TA system TA125198

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/ParD(antitoxin)
• Location: 5202496..5203494
• Replicon: chromosome
• Accession: NZ_CP040255
• Organism: Mycobacterium avium subsp. hominissuis strain 101115

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: X7VT18
• Locus tag: FCV18_RS25325
• Protein ID: WP_003876749.1
• Coordinates: 5202496..5203074 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A049EEK5
• Locus tag: FCV18_RS25330
• Protein ID: WP_009976725.1
• Coordinates: 5203105..5203494 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCV18_RS25300	5198488..5199420	-	933	WP_011724814.1	sigma-70 family RNA polymerase sigma factor	-
FCV18_RS25305	5199589..5199939	+	351	WP_011724813.1	DoxX family protein	-
FCV18_RS25310	5199953..5200753	-	801	WP_011724812.1	nuclear transport factor 2 family protein	-
FCV18_RS25315	5200753..5201313	-	561	WP_011724811.1	pyrazinamidase PncA	-
FCV18_RS25320	5201424..5202491	+	1068	WP_003876748.1	DoxX family membrane protein	-
FCV18_RS25325	5202496..5203074	-	579	WP_003876749.1	zeta toxin family protein	Toxin
FCV18_RS25330	5203105..5203494	-	390	WP_009976725.1	hypothetical protein	Antitoxin
FCV18_RS25335	5203575..5204069	-	495	WP_062890592.1	gluconokinase	-
FCV18_RS25340	5204066..5206064	-	1999	Protein_4828	phosphotransferase	-
FCV18_RS25345	5206083..5207600	-	1518	WP_023865875.1	carboxylesterase/lipase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (5-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21034.18 Da
• Isoelectric Point: 10.6678

>T125198 WP_003876749.1 NZ_CP040255:c5203074-5202496 [Mycobacterium avium subsp. hominissuis]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV

Nucleotide

• Length: 579 bp

>T125198 NZ_CP040255:c5203074-5202496 [Mycobacterium avium subsp. hominissuis]
ATGGAGCGACTCGACGTGGTGGTCGGGCCCAACGGCGCCGGCAAGTCGACGTTCATCGCGTTGACCCTGGCGCCGCTGCT
GCCGGGCAGCGTGGTGGTCAACGCCGACGAGATCGCGCGGCAGCGCTGGCCGCAGGATCCGGCGTCGCACGCCTACGACG
CCGCGAAGGTCGCCGCCGACACCCGGGCGAAGCTGATCGACCTGGGCCGGTCGTTCATCGCCGAGACCGTGTTCTCCCAC
CCGTCCAAGCTGGACCTGCTGCATGCCGCCCGCCGCGCCGGCTTCACCGTCGTGCTGCACGTGCTGCTCATCCCGGAAGA
CCTTGCCGTCGAACGGGTCCGGCACCGCGTGCGGGCCGGCGGCCATGACGTGCCGGAAACCAAGATCCGCGAGCGGCATC
GCCGGTTGTGGACTCCGGTCGCCGAGGCGATGACCCTGGCCGACCTGGCCACCGGCTACGACAACAGCCGGCTGCGCGGG
CCGCGTGTGGTGGCCCGGCTCAGCGGCGGGCTGACGGTCGGTGCCGTCGACTGGCCGGCGTGGGCACCCGAGACCTTGCG
GTCGCGTTGGCCGGTCTAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13598.04 Da
• Isoelectric Point: 5.6717

>AT125198 WP_009976725.1 NZ_CP040255:c5203494-5203105 [Mycobacterium avium subsp. hominissuis]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTVEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR

Nucleotide

• Length: 390 bp

>AT125198 NZ_CP040255:c5203494-5203105 [Mycobacterium avium subsp. hominissuis]
ATGGCCGAGGCCGTCGATCGGGTCACCCGGGTCGCGTCCGATCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGTCAGAG
CCGCTCGGCCAAGCAGCAGCTCGACCACTGGGCGCGGGTCGGGCGTGCGGTGTCCAGCCAGCACACCGCGTCCCGGCGGC
GGGTCGAAGCCGCGCTGGCCGGCCGGCTGTCCACCGCCGAACTCACCGTCGAAGAGGGCGTGGTGTTCAACGCCGAGATC
TCGGCGGCCATCGACGAAAGCCTGGCGCGCACCAACTACGGGGCGACGCTGGCCGGGCAGGGTGTCACCACGGTGGCCCT
CAACGACGATGGCGAGATCGTCGAGCACCGGCCCGACGGCACCGCGGTGGTGCTGGCCGGCCGGCGCTGA

Structures

Toxin

• AlphaFold DB: A0A0E2W6B4

Antitoxin

• AlphaFold DB: A0A049EEK5