Detailed information of TA system TA125197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 3910780..3911344
• Replicon: chromosome
• Accession: NZ_CP040255
• Organism: Mycobacterium avium subsp. hominissuis strain 101115

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: X7VBD8
• Locus tag: FCV18_RS19690
• Protein ID: WP_003875391.1
• Coordinates: 3910973..3911344 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FCV18_RS19685
• Protein ID: WP_011724021.1
• Coordinates: 3910780..3910986 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCV18_RS19665	3906217..3906441	-	225	Protein_3712	transposase	-
FCV18_RS19670	3906485..3908428	-	1944	WP_007172497.1	tyrosine-type recombinase/integrase	-
FCV18_RS19675	3908425..3909475	-	1051	Protein_3714	tyrosine-type recombinase/integrase	-
FCV18_RS19680	3909591..3910601	-	1011	Protein_3715	IS256-like element IS1311 family transposase	-
FCV18_RS19685	3910780..3910986	+	207	WP_011724021.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FCV18_RS19690	3910973..3911344	+	372	WP_003875391.1	type II toxin-antitoxin system VapC family toxin	Toxin
FCV18_RS19695	3911444..3911884	+	441	WP_003875392.1	nitroreductase family deazaflavin-dependent oxidoreductase	-
FCV18_RS19700	3911950..3912630	-	681	WP_137987618.1	SDR family oxidoreductase	-
FCV18_RS19705	3912599..3912937	-	339	WP_062887574.1	DUF3024 domain-containing protein	-
FCV18_RS19710	3912942..3913521	-	580	Protein_3721	hypothetical protein	-
FCV18_RS19715	3913567..3914359	-	793	Protein_3722	ATP-binding protein	-
FCV18_RS19720	3914356..3915941	-	1586	Protein_3723	IS21 family transposase	-
FCV18_RS19725	3916153..3916335	-	183	Protein_3724	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3913567..3914019	452

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13770.14 Da
• Isoelectric Point: 6.6003

>T125197 WP_003875391.1 NZ_CP040255:3910973-3911344 [Mycobacterium avium subsp. hominissuis]
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVECHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL

Nucleotide

• Length: 372 bp

>T125197 NZ_CP040255:3910973-3911344 [Mycobacterium avium subsp. hominissuis]
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGCTGACGCATGCGGAGGTCCTTCATCTCGTCGAATGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTTGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7261.25 Da
• Isoelectric Point: 11.0634

>AT125197 WP_011724021.1 NZ_CP040255:3910780-3910986 [Mycobacterium avium subsp. hominissuis]
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRTPADDSR

Nucleotide

• Length: 207 bp

>AT125197 NZ_CP040255:3910780-3910986 [Mycobacterium avium subsp. hominissuis]
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGACACCCGCCGATGATTCTCGTTGA

Structures

Toxin

• AlphaFold DB: A0A0E2WB37