Detailed information of TA system TA125195

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD(antitoxin)
• Location: 3490691..3491374
• Replicon: chromosome
• Accession: NZ_CP040255
• Organism: Mycobacterium avium subsp. hominissuis strain 101115

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D5PEA4
• Locus tag: FCV18_RS17615
• Protein ID: WP_007168487.1
• Coordinates: 3490691..3491098 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FCV18_RS17620
• Protein ID: WP_137987485.1
• Coordinates: 3491102..3491374 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCV18_RS17595	3486367..3487957	-	1591	Protein_3310	IS21 family transposase	-
FCV18_RS17605	3489963..3490268	-	306	WP_007168485.1	hypothetical protein	-
FCV18_RS17610	3490329..3490670	-	342	WP_007168486.1	hypothetical protein	-
FCV18_RS17615	3490691..3491098	-	408	WP_007168487.1	type II toxin-antitoxin system VapC family toxin	Toxin
FCV18_RS17620	3491102..3491374	-	273	WP_137987485.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FCV18_RS17625	3491864..3492082	-	219	Protein_3315	transposase	-
FCV18_RS17630	3492128..3494070	-	1943	Protein_3316	tyrosine-type recombinase/integrase	-
FCV18_RS17635	3494067..3495116	-	1050	WP_007172498.1	tyrosine-type recombinase/integrase	-
FCV18_RS17640	3495233..3496246	-	1014	Protein_3318	IS256-like element IS1511 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3477918..3500934	23016
	-	flank	IS/Tn	-	-	3485579..3486370	791

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14464.55 Da
• Isoelectric Point: 4.6697

>T125195 WP_007168487.1 NZ_CP040255:c3491098-3490691 [Mycobacterium avium subsp. hominissuis]
VIYLDTSALVKLIRIEVESDALADWLDERTETRWITSALAEVELPRAIRAVAPNGLSAVPSVLARLDRFEIDQVIRATAA
AYPDPALRSLDAIHLATAQIAASTAPLTAMVAYDSRLSDAARALGITIVTPGRNS

Nucleotide

• Length: 408 bp

>T125195 NZ_CP040255:c3491098-3490691 [Mycobacterium avium subsp. hominissuis]
GTGATCTACCTGGATACCTCGGCTCTGGTCAAGCTGATCCGGATCGAAGTCGAATCTGATGCTCTAGCTGACTGGCTCGA
TGAACGCACCGAAACACGTTGGATAACATCTGCCTTGGCTGAAGTGGAGCTCCCCAGAGCCATCCGCGCAGTCGCCCCAA
ATGGCTTATCTGCTGTCCCCTCTGTGCTGGCCAGACTGGATCGGTTCGAAATCGACCAGGTCATCCGCGCCACCGCGGCC
GCCTACCCCGATCCGGCGCTGCGCTCGCTCGATGCGATACACCTGGCCACCGCTCAAATCGCCGCATCCACAGCACCATT
GACCGCCATGGTCGCCTATGACAGTCGACTCAGCGACGCCGCCCGTGCCCTCGGGATAACGATTGTCACACCTGGAAGAA
ACTCATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9734.37 Da
• Isoelectric Point: 10.1954

>AT125195 WP_137987485.1 NZ_CP040255:c3491374-3491102 [Mycobacterium avium subsp. hominissuis]
MSVVPLRMLNQETAKVLARVKRGEEITLTERGEVIARIIPATAGPLDALITAGRVQPATLAGPAPRPTVPMHDNLDAGAL
LQRLRAEERY

Nucleotide

• Length: 273 bp

>AT125195 NZ_CP040255:c3491374-3491102 [Mycobacterium avium subsp. hominissuis]
ATGAGTGTAGTACCTCTCCGAATGCTCAACCAAGAGACGGCAAAGGTCTTGGCCCGCGTCAAGCGTGGCGAAGAGATCAC
GCTTACTGAGCGCGGGGAAGTCATCGCCCGAATAATCCCCGCTACCGCCGGCCCACTGGATGCGTTGATCACTGCCGGCA
GAGTGCAACCGGCGACGCTGGCCGGCCCAGCCCCGCGGCCGACCGTTCCGATGCACGACAATCTCGACGCCGGCGCGCTA
TTGCAACGTCTGCGCGCCGAGGAAAGGTATTAG

Structures

Toxin

• AlphaFold DB: A0A1X1XAJ9