Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 3352122..3352651 Replicon chromosome
Accession NZ_CP040255
Organism Mycobacterium avium subsp. hominissuis strain 101115

Toxin (Protein)


Gene name Rv0299 Uniprot ID X7VD93
Locus tag FCV18_RS16965 Protein ID WP_007172144.1
Coordinates 3352122..3352427 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID D5P1N8
Locus tag FCV18_RS16970 Protein ID WP_007172145.1
Coordinates 3352424..3352651 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCV18_RS25770 3347200..3347340 + 141 WP_007172137.1 hypothetical protein -
FCV18_RS16935 3347337..3347723 + 387 WP_007172138.1 YbaB/EbfC family nucleoid-associated protein -
FCV18_RS16940 3347793..3348470 + 678 WP_101930854.1 hypothetical protein -
FCV18_RS16945 3348470..3348802 + 333 WP_033717256.1 hypothetical protein -
FCV18_RS16950 3349090..3349377 + 288 WP_007172141.1 hypothetical protein -
FCV18_RS25775 3349396..3351750 + 2355 WP_007172142.1 hypothetical protein -
FCV18_RS16965 3352122..3352427 - 306 WP_007172144.1 hypothetical protein Toxin
FCV18_RS16970 3352424..3352651 - 228 WP_007172145.1 ribbon-helix-helix protein, CopG family Antitoxin
FCV18_RS16980 3353137..3354627 + 1491 WP_007172147.1 type VII secretion protein EccB -
FCV18_RS16985 3354701..3355756 + 1056 WP_007172148.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 10428.23 Da        Isoelectric Point: 3.9382

>T125194 WP_007172144.1 NZ_CP040255:c3352427-3352122 [Mycobacterium avium subsp. hominissuis]
VITPGDITPGRDTNQELYVVVLSNTIHLAAATGQVIICPFIPGEIPSSTMAMIVTVLQPKGVVLPELIQWLPVAALDQPI
GNIGGIALADTTTTAVTALIS

Download         Length: 306 bp

>T125194 NZ_CP040255:c3352427-3352122 [Mycobacterium avium subsp. hominissuis]
GTGATCACACCCGGAGACATCACGCCAGGCCGCGACACCAACCAGGAACTGTACGTTGTCGTACTATCTAACACGATTCA
CCTCGCAGCCGCCACCGGCCAGGTGATCATCTGCCCCTTCATTCCCGGTGAAATCCCCAGCAGCACAATGGCTATGATCG
TCACAGTGCTGCAACCCAAAGGGGTTGTCTTACCGGAGCTCATCCAGTGGCTTCCTGTCGCGGCCCTCGACCAACCCATC
GGCAATATCGGCGGCATCGCGCTCGCTGACACGACCACGACCGCCGTCACCGCGCTCATTTCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8153.21 Da        Isoelectric Point: 5.0079

>AT125194 WP_007172145.1 NZ_CP040255:c3352651-3352424 [Mycobacterium avium subsp. hominissuis]
MAKAKVSVMIEEAVLAAADADAQAAGLNRSEMIERALHNEHLRISLENYTTHTVPTLDIDAYAEKVYQANRAAGL

Download         Length: 228 bp

>AT125194 NZ_CP040255:c3352651-3352424 [Mycobacterium avium subsp. hominissuis]
ATGGCGAAAGCCAAAGTGTCCGTAATGATTGAAGAGGCCGTGCTGGCGGCGGCCGATGCGGACGCCCAGGCGGCCGGGCT
GAATCGTTCAGAGATGATCGAACGAGCCCTGCACAACGAGCATCTCCGAATCTCGCTCGAGAACTACACAACACACACTG
TGCCAACGCTCGACATCGACGCCTACGCGGAGAAGGTCTATCAGGCGAACCGGGCCGCTGGCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XDZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XDJ0

References