Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 250486..251150 Replicon chromosome
Accession NZ_CP040255
Organism Mycobacterium avium subsp. hominissuis strain 101115

Toxin (Protein)


Gene name vapC Uniprot ID A0A2A2ZII2
Locus tag FCV18_RS01815 Protein ID WP_023861453.1
Coordinates 250486..250893 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2A2ZI58
Locus tag FCV18_RS01820 Protein ID WP_033719712.1
Coordinates 250890..251150 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCV18_RS01790 245778..246323 - 546 WP_033719715.1 carboxymuconolactone decarboxylase family protein -
FCV18_RS01795 246320..246841 - 522 WP_033719714.1 carboxymuconolactone decarboxylase family protein -
FCV18_RS01800 247078..247973 + 896 Protein_220 serine/threonine protein kinase -
FCV18_RS01805 248135..249601 + 1467 WP_019733492.1 IS1634 family transposase -
FCV18_RS01810 249617..250339 + 723 Protein_222 serine/threonine protein kinase -
FCV18_RS01815 250486..250893 - 408 WP_023861453.1 type II toxin-antitoxin system VapC family toxin Toxin
FCV18_RS01820 250890..251150 - 261 WP_033719712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FCV18_RS01825 251331..251783 - 453 WP_033719711.1 VOC family protein -
FCV18_RS01830 251949..253217 + 1269 WP_033719710.1 cytochrome P450 -
FCV18_RS01835 253415..254875 - 1461 WP_033719709.1 serine/threonine protein kinase -
FCV18_RS01840 255070..255732 - 663 WP_023861449.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 248090..249601 1511


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14414.44 Da        Isoelectric Point: 4.5860

>T125192 WP_023861453.1 NZ_CP040255:c250893-250486 [Mycobacterium avium subsp. hominissuis]
MTARPAAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAAR
MWARLRIHLAEAGRRMRANDLWIAAIAASRGLPVVTQDDDFAALDGAANLAIIRV

Download         Length: 408 bp

>T125192 NZ_CP040255:c250893-250486 [Mycobacterium avium subsp. hominissuis]
ATGACTGCAAGGCCGGCGGCCGGGGTGCTCGACACCTCGGTGTTCATCGCGTCCGAAAGCGGACGGCACCTGGACGAGGC
GCGAATCCCCGACGAGGTAGCCACCACCGTCATCACCCTTGCCGAACTTCACGCCGGCGTATTAGCCGCGACGACGTCCG
ACGTTCGGGCGCAACGCCTCGCAACGCTGGAATCGATAGCGGATATGGAAATGTTGCCAGTCGACGACGACGCAGCCCGC
ATGTGGGCAAGGTTGCGGATCCACCTAGCCGAGGCTGGACGGCGGATGCGGGCTAATGATCTGTGGATCGCGGCGATCGC
GGCATCGCGGGGACTGCCCGTCGTCACCCAGGATGACGACTTCGCCGCACTCGACGGCGCGGCGAACCTGGCGATTATTC
GGGTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9608.98 Da        Isoelectric Point: 11.7137

>AT125192 WP_033719712.1 NZ_CP040255:c251150-250890 [Mycobacterium avium subsp. hominissuis]
MSEVASRELRNDTAGVLRRVREGEDVTITINGRAVAMLTALRPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT125192 NZ_CP040255:c251150-250890 [Mycobacterium avium subsp. hominissuis]
ATGTCTGAAGTGGCGTCTCGCGAGCTGCGCAACGATACGGCGGGGGTACTGCGGCGCGTGCGGGAAGGGGAGGACGTCAC
CATCACCATCAACGGCCGAGCCGTCGCGATGCTGACCGCGCTGCGGCCGCAGCGACGGCGGTGGCTGAGCAAGGCGGAGT
TGCTGTCGCGCTTGCGCCGCGCGCAAGCCGATCCCGGGCTACGCCAAGACCTCGCAACCCTTGCAGGCGACACCACTGAG
GACCTCGGTCCGATCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2ZII2

Antitoxin

Source ID Structure
AlphaFold DB A0A2A2ZI58

References