Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3698558..3699222 Replicon chromosome
Accession NZ_CP040250
Organism Mycobacterium avium subsp. hominissuis strain 101174

Toxin (Protein)


Gene name vapC Uniprot ID A0A2A2ZII2
Locus tag FCV17_RS17785 Protein ID WP_023861453.1
Coordinates 3698558..3698965 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2A2ZI58
Locus tag FCV17_RS17790 Protein ID WP_033719712.1
Coordinates 3698962..3699222 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCV17_RS17760 3693850..3694395 - 546 WP_033719715.1 carboxymuconolactone decarboxylase family protein -
FCV17_RS17765 3694392..3694913 - 522 WP_033719714.1 carboxymuconolactone decarboxylase family protein -
FCV17_RS17770 3695150..3696045 + 896 Protein_3421 serine/threonine protein kinase -
FCV17_RS17775 3696207..3697673 + 1467 WP_019733492.1 IS1634 family transposase -
FCV17_RS17780 3697689..3698411 + 723 Protein_3423 serine/threonine protein kinase -
FCV17_RS17785 3698558..3698965 - 408 WP_023861453.1 type II toxin-antitoxin system VapC family toxin Toxin
FCV17_RS17790 3698962..3699222 - 261 WP_033719712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FCV17_RS17795 3699403..3699855 - 453 WP_033719711.1 VOC family protein -
FCV17_RS17800 3700021..3701289 + 1269 WP_033719710.1 cytochrome P450 -
FCV17_RS17805 3701487..3702947 - 1461 WP_033719709.1 serine/threonine protein kinase -
FCV17_RS17810 3703142..3703804 - 663 WP_023861449.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3696162..3697673 1511


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14414.44 Da        Isoelectric Point: 4.5860

>T125191 WP_023861453.1 NZ_CP040250:c3698965-3698558 [Mycobacterium avium subsp. hominissuis]
MTARPAAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAAR
MWARLRIHLAEAGRRMRANDLWIAAIAASRGLPVVTQDDDFAALDGAANLAIIRV

Download         Length: 408 bp

>T125191 NZ_CP040250:c3698965-3698558 [Mycobacterium avium subsp. hominissuis]
ATGACTGCAAGGCCGGCGGCCGGGGTGCTCGACACCTCGGTGTTCATCGCGTCCGAAAGCGGACGGCACCTGGACGAGGC
GCGAATCCCCGACGAGGTAGCCACCACCGTCATCACCCTTGCCGAACTTCACGCCGGCGTATTAGCCGCGACGACGTCCG
ACGTTCGGGCGCAACGCCTCGCAACGCTGGAATCGATAGCGGATATGGAAATGTTGCCAGTCGACGACGACGCAGCCCGC
ATGTGGGCAAGGTTGCGGATCCACCTAGCCGAGGCTGGACGGCGGATGCGGGCTAATGATCTGTGGATCGCGGCGATCGC
GGCATCGCGGGGACTGCCCGTCGTCACCCAGGATGACGACTTCGCCGCACTCGACGGCGCGGCGAACCTGGCGATTATTC
GGGTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9608.98 Da        Isoelectric Point: 11.7137

>AT125191 WP_033719712.1 NZ_CP040250:c3699222-3698962 [Mycobacterium avium subsp. hominissuis]
MSEVASRELRNDTAGVLRRVREGEDVTITINGRAVAMLTALRPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT125191 NZ_CP040250:c3699222-3698962 [Mycobacterium avium subsp. hominissuis]
ATGTCTGAAGTGGCGTCTCGCGAGCTGCGCAACGATACGGCGGGGGTACTGCGGCGCGTGCGGGAAGGGGAGGACGTCAC
CATCACCATCAACGGCCGAGCCGTCGCGATGCTGACCGCGCTGCGGCCGCAGCGACGGCGGTGGCTGAGCAAGGCGGAGT
TGCTGTCGCGCTTGCGCCGCGCGCAAGCCGATCCCGGGCTACGCCAAGACCTCGCAACCCTTGCAGGCGACACCACTGAG
GACCTCGGTCCGATCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2ZII2

Antitoxin

Source ID Structure
AlphaFold DB A0A2A2ZI58

References