Detailed information of TA system TA125190

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/ParD(antitoxin)
• Location: 3395891..3396889
• Replicon: chromosome
• Accession: NZ_CP040250
• Organism: Mycobacterium avium subsp. hominissuis strain 101174

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: X7VT18
• Locus tag: FCV17_RS16445
• Protein ID: WP_003876749.1
• Coordinates: 3395891..3396469 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A049EEK5
• Locus tag: FCV17_RS16450
• Protein ID: WP_009976725.1
• Coordinates: 3396500..3396889 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCV17_RS16420	3391883..3392815	-	933	WP_011724814.1	sigma-70 family RNA polymerase sigma factor	-
FCV17_RS16425	3392984..3393334	+	351	WP_011724813.1	DoxX family protein	-
FCV17_RS16430	3393348..3394148	-	801	WP_011724812.1	nuclear transport factor 2 family protein	-
FCV17_RS16435	3394148..3394708	-	561	WP_011724811.1	pyrazinamidase PncA	-
FCV17_RS16440	3394819..3395886	+	1068	WP_003876748.1	DoxX family membrane protein	-
FCV17_RS16445	3395891..3396469	-	579	WP_003876749.1	zeta toxin family protein	Toxin
FCV17_RS16450	3396500..3396889	-	390	WP_009976725.1	hypothetical protein	Antitoxin
FCV17_RS16455	3396970..3397464	-	495	WP_062890592.1	gluconokinase	-
FCV17_RS16460	3397461..3399458	-	1998	WP_062890593.1	phosphotransferase	-
FCV17_RS16465	3399477..3400994	-	1518	WP_023865875.1	carboxylesterase/lipase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (5-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21034.18 Da
• Isoelectric Point: 10.6678

>T125190 WP_003876749.1 NZ_CP040250:c3396469-3395891 [Mycobacterium avium subsp. hominissuis]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV

Nucleotide

• Length: 579 bp

>T125190 NZ_CP040250:c3396469-3395891 [Mycobacterium avium subsp. hominissuis]
ATGGAGCGACTCGACGTGGTGGTCGGGCCCAACGGCGCCGGCAAGTCGACGTTCATCGCGTTGACCCTGGCGCCGCTGCT
GCCGGGCAGCGTGGTGGTCAACGCCGACGAGATCGCGCGGCAGCGCTGGCCGCAGGATCCGGCGTCGCACGCCTACGACG
CCGCGAAGGTCGCCGCCGACACCCGGGCGAAGCTGATCGACCTGGGCCGGTCGTTCATCGCCGAGACCGTGTTCTCCCAC
CCGTCCAAGCTGGACCTGCTGCATGCCGCCCGCCGCGCCGGCTTCACCGTCGTGCTGCACGTGCTGCTCATCCCGGAAGA
CCTTGCCGTCGAACGGGTCCGGCACCGCGTGCGGGCCGGCGGCCATGACGTGCCGGAAACCAAGATCCGCGAGCGGCATC
GCCGGTTGTGGACTCCGGTCGCCGAGGCGATGACCCTGGCCGACCTGGCCACCGGCTACGACAACAGCCGGCTGCGCGGG
CCGCGTGTGGTGGCCCGGCTCAGCGGCGGGCTGACGGTCGGTGCCGTCGACTGGCCGGCGTGGGCACCCGAGACCTTGCG
GTCGCGTTGGCCGGTCTAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13598.04 Da
• Isoelectric Point: 5.6717

>AT125190 WP_009976725.1 NZ_CP040250:c3396889-3396500 [Mycobacterium avium subsp. hominissuis]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTVEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR

Nucleotide

• Length: 390 bp

>AT125190 NZ_CP040250:c3396889-3396500 [Mycobacterium avium subsp. hominissuis]
ATGGCCGAGGCCGTCGATCGGGTCACCCGGGTCGCGTCCGATCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGTCAGAG
CCGCTCGGCCAAGCAGCAGCTCGACCACTGGGCGCGGGTCGGGCGTGCGGTGTCCAGCCAGCACACCGCGTCCCGGCGGC
GGGTCGAAGCCGCGCTGGCCGGCCGGCTGTCCACCGCCGAACTCACCGTCGAAGAGGGCGTGGTGTTCAACGCCGAGATC
TCGGCGGCCATCGACGAAAGCCTGGCGCGCACCAACTACGGGGCGACGCTGGCCGGGCAGGGTGTCACCACGGTGGCCCT
CAACGACGATGGCGAGATCGTCGAGCACCGGCCCGACGGCACCGCGGTGGTGCTGGCCGGCCGGCGCTGA

Structures

Toxin

• AlphaFold DB: A0A0E2W6B4

Antitoxin

• AlphaFold DB: A0A049EEK5