Detailed information of TA system TA125189

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2121346..2121910
• Replicon: chromosome
• Accession: NZ_CP040250
• Organism: Mycobacterium avium subsp. hominissuis strain 101174

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: X7VBD8
• Locus tag: FCV17_RS10840
• Protein ID: WP_003875391.1
• Coordinates: 2121539..2121910 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FCV17_RS10835
• Protein ID: WP_011724021.1
• Coordinates: 2121346..2121552 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCV17_RS10815	2116782..2117006	-	225	Protein_2051	transposase	-
FCV17_RS10820	2117050..2118992	-	1943	Protein_2052	tyrosine-type recombinase/integrase	-
FCV17_RS10825	2118989..2120039	-	1051	Protein_2053	tyrosine-type recombinase/integrase	-
FCV17_RS10830	2120153..2121167	-	1015	Protein_2054	IS256-like element IS1311 family transposase	-
FCV17_RS10835	2121346..2121552	+	207	WP_011724021.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FCV17_RS10840	2121539..2121910	+	372	WP_003875391.1	type II toxin-antitoxin system VapC family toxin	Toxin
FCV17_RS10845	2122010..2122450	+	441	WP_003875392.1	nitroreductase family deazaflavin-dependent oxidoreductase	-
FCV17_RS10850	2122516..2123074	-	559	Protein_2058	SDR family oxidoreductase	-
FCV17_RS10855	2123164..2123502	-	339	WP_062887574.1	DUF3024 domain-containing protein	-
FCV17_RS10860	2123507..2124085	-	579	WP_062895398.1	hypothetical protein	-
FCV17_RS10865	2124131..2124921	-	791	Protein_2061	ATP-binding protein	-
FCV17_RS10870	2124918..2126504	-	1587	Protein_2062	IS21 family transposase	-
FCV17_RS10875	2126716..2126898	-	183	Protein_2063	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2115658..2134751	19093

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13770.14 Da
• Isoelectric Point: 6.6003

>T125189 WP_003875391.1 NZ_CP040250:2121539-2121910 [Mycobacterium avium subsp. hominissuis]
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVECHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL

Nucleotide

• Length: 372 bp

>T125189 NZ_CP040250:2121539-2121910 [Mycobacterium avium subsp. hominissuis]
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGCTGACGCATGCGGAGGTCCTTCATCTCGTCGAATGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTTGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7261.25 Da
• Isoelectric Point: 11.0634

>AT125189 WP_011724021.1 NZ_CP040250:2121346-2121552 [Mycobacterium avium subsp. hominissuis]
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRTPADDSR

Nucleotide

• Length: 207 bp

>AT125189 NZ_CP040250:2121346-2121552 [Mycobacterium avium subsp. hominissuis]
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGACACCCGCCGATGATTCTCGTTGA

Structures

Toxin

• AlphaFold DB: A0A0E2WB37