Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 1725603..1726286 Replicon chromosome
Accession NZ_CP040250
Organism Mycobacterium avium subsp. hominissuis strain 101174

Toxin (Protein)


Gene name vapC Uniprot ID D5PEA4
Locus tag FCV17_RS08860 Protein ID WP_007168487.1
Coordinates 1725603..1726010 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X1XBB9
Locus tag FCV17_RS08865 Protein ID WP_033711258.1
Coordinates 1726014..1726286 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCV17_RS08840 1721283..1722869 - 1587 WP_062887208.1 IS21 family transposase -
FCV17_RS08850 1724875..1725180 - 306 WP_007168485.1 hypothetical protein -
FCV17_RS08855 1725241..1725582 - 342 WP_007168486.1 hypothetical protein -
FCV17_RS08860 1725603..1726010 - 408 WP_007168487.1 type II toxin-antitoxin system VapC family toxin Toxin
FCV17_RS08865 1726014..1726286 - 273 WP_033711258.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FCV17_RS08870 1726776..1726994 - 219 Protein_1672 transposase -
FCV17_RS08875 1727040..1728981 - 1942 Protein_1673 tyrosine-type recombinase/integrase -
FCV17_RS08880 1728978..1730027 - 1050 Protein_1674 tyrosine-type recombinase/integrase -
FCV17_RS08885 1730144..1731157 - 1014 Protein_1675 IS256-like element IS1511 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1710280..1740107 29827
- flank IS/Tn - - 1730096..1731157 1061


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14464.55 Da        Isoelectric Point: 4.6697

>T125187 WP_007168487.1 NZ_CP040250:c1726010-1725603 [Mycobacterium avium subsp. hominissuis]
VIYLDTSALVKLIRIEVESDALADWLDERTETRWITSALAEVELPRAIRAVAPNGLSAVPSVLARLDRFEIDQVIRATAA
AYPDPALRSLDAIHLATAQIAASTAPLTAMVAYDSRLSDAARALGITIVTPGRNS

Download         Length: 408 bp

>T125187 NZ_CP040250:c1726010-1725603 [Mycobacterium avium subsp. hominissuis]
GTGATCTACCTGGATACCTCGGCTCTGGTCAAGCTGATCCGGATCGAAGTCGAATCTGATGCTCTAGCTGACTGGCTCGA
TGAACGCACCGAAACACGTTGGATAACATCTGCCTTGGCTGAAGTGGAGCTCCCCAGAGCCATCCGCGCAGTCGCCCCAA
ATGGCTTATCTGCTGTCCCCTCTGTGCTGGCCAGACTGGATCGGTTCGAAATCGACCAGGTCATCCGCGCCACCGCGGCC
GCCTACCCCGATCCGGCGCTGCGCTCGCTCGATGCGATACACCTGGCCACCGCTCAAATCGCCGCATCCACAGCACCATT
GACCGCCATGGTCGCCTATGACAGTCGACTCAGCGACGCCGCCCGTGCCCTCGGGATAACGATTGTCACACCTGGAAGAA
ACTCATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9764.35 Da        Isoelectric Point: 8.7382

>AT125187 WP_033711258.1 NZ_CP040250:c1726286-1726014 [Mycobacterium avium subsp. hominissuis]
MSEVPLRMLNQETAKVLARVKRGEEITLTERGEVIARIIPATAGPLDALITAGRVQPATLAGPAPRPTVPMHDNLDAGAL
LQRLRAEERY

Download         Length: 273 bp

>AT125187 NZ_CP040250:c1726286-1726014 [Mycobacterium avium subsp. hominissuis]
ATGAGTGAAGTACCTCTCCGAATGCTCAACCAAGAGACGGCAAAGGTCTTGGCCCGCGTCAAGCGTGGCGAAGAGATCAC
GCTTACTGAGCGCGGGGAAGTCATCGCCCGAATAATCCCCGCTACCGCCGGCCCACTGGATGCGTTGATCACTGCCGGCA
GAGTGCAACCGGCGACGCTGGCCGGCCCAGCCCCGCGGCCGACCGTTCCGATGCACGACAATCTCGACGCCGGCGCGCTA
TTGCAACGTCTGCGCGCCGAGGAAAGGTATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XAJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XBB9

References