Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 1672943..1673610 Replicon chromosome
Accession NZ_CP040250
Organism Mycobacterium avium subsp. hominissuis strain 101174

Toxin (Protein)


Gene name vapC Uniprot ID D5PE24
Locus tag FCV17_RS08610 Protein ID WP_007168407.1
Coordinates 1673218..1673610 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5PE23
Locus tag FCV17_RS08605 Protein ID WP_007168406.1
Coordinates 1672943..1673218 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCV17_RS08580 1669014..1670225 - 1212 Protein_1616 ISL3 family transposase -
FCV17_RS08585 1670364..1670987 - 624 Protein_1617 DDE-type integrase/transposase/recombinase -
FCV17_RS08590 1670990..1671079 - 90 Protein_1618 SDR family oxidoreductase -
FCV17_RS08595 1671132..1671835 - 704 Protein_1619 histidine phosphatase family protein -
FCV17_RS08600 1671918..1672790 + 873 WP_007168405.1 MaoC family dehydratase N-terminal domain-containing protein -
FCV17_RS08605 1672943..1673218 + 276 WP_007168406.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FCV17_RS08610 1673218..1673610 + 393 WP_007168407.1 type II toxin-antitoxin system VapC family toxin Toxin
FCV17_RS08615 1673758..1674920 - 1163 Protein_1623 trehalose-phosphatase -
FCV17_RS08620 1674962..1676300 - 1339 Protein_1624 DUF1298 domain-containing protein -
FCV17_RS08625 1676561..1676683 - 123 Protein_1625 IS1595 family transposase -
FCV17_RS08630 1677020..1678354 + 1335 Protein_1626 IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1617767..1698910 81143


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14305.73 Da        Isoelectric Point: 10.5032

>T125186 WP_007168407.1 NZ_CP040250:1673218-1673610 [Mycobacterium avium subsp. hominissuis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Download         Length: 393 bp

>T125186 NZ_CP040250:1673218-1673610 [Mycobacterium avium subsp. hominissuis]
ATGGCGGCCATCTACCTGGACTCGTCCGCAATCGTCAAGCTTGCAGTTCGTGAGCCAGAGTCGGATGCGCTGCGTCGCTA
CCTTCGCACCCGGCTGCCGCGGGTGTCGAGTGCCCTTGCGCGGACGGAGGTCATGCGGGCTCTGCTCCACAAGGGTGAAT
CAGCCCGAAGAGCCGGACGCCGGGCGCTCGCGAGCCTAGACCTACTACGCATCGACAACCGATTGCTCGATCTTGCTGGT
GGGCTGCTGCCAATCGAGCTACGCACCCTCGATGCAATTCACCTGGCGACTGCCCAGCGGCTCGGCATGGATCTTGGCCG
GTTGTGCACTTACGACGACCGCATGCGCGACGCCGCCGAGGCGCTCGGCATGGCAGTGATTGCCCCGTCTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10150.63 Da        Isoelectric Point: 5.1881

>AT125186 WP_007168406.1 NZ_CP040250:1672943-1673218 [Mycobacterium avium subsp. hominissuis]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Download         Length: 276 bp

>AT125186 NZ_CP040250:1672943-1673218 [Mycobacterium avium subsp. hominissuis]
ATGTCTACGGTGGGCGTTCGTGAGCTGCGGCAGCGGGCCAGCGAACTCCTCCGTCGGGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGTGGTCGGCCTATCGCCCTTCTCTCGCCGATGCCGGAGGGCGGTCCGTACCAGCAGATGCTGGCAAGCG
GCGGGATCGAACGTGCGACGCTTGACTTTGATGACCTTCCCGAGCCGGTCCGACTCAAAACGGGTATCGAGCTGCCGTCC
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XV84

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XUZ3

References