Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 2198509..2199173 Replicon chromosome
Accession NZ_CP040247
Organism Mycobacterium avium subsp. hominissuis strain 101034

Toxin (Protein)


Gene name vapC Uniprot ID A0A2A2ZII2
Locus tag FCV16_RS10325 Protein ID WP_023861453.1
Coordinates 2198509..2198916 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2A2ZI58
Locus tag FCV16_RS10330 Protein ID WP_033719712.1
Coordinates 2198913..2199173 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCV16_RS10300 2193802..2194347 - 546 WP_033719715.1 carboxymuconolactone decarboxylase family protein -
FCV16_RS10305 2194344..2194865 - 522 WP_033719714.1 carboxymuconolactone decarboxylase family protein -
FCV16_RS10310 2195102..2195997 + 896 Protein_1957 serine/threonine protein kinase -
FCV16_RS10315 2196159..2197624 + 1466 Protein_1958 IS1634 family transposase -
FCV16_RS10320 2197640..2198362 + 723 Protein_1959 serine/threonine protein kinase -
FCV16_RS10325 2198509..2198916 - 408 WP_023861453.1 type II toxin-antitoxin system VapC family toxin Toxin
FCV16_RS10330 2198913..2199173 - 261 WP_033719712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FCV16_RS10335 2199354..2199806 - 453 WP_033719711.1 VOC family protein -
FCV16_RS10340 2199972..2201238 + 1267 Protein_1963 cytochrome P450 -
FCV16_RS10345 2201436..2202896 - 1461 WP_033719709.1 serine/threonine protein kinase -
FCV16_RS10350 2203091..2203753 - 663 WP_023861449.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14414.44 Da        Isoelectric Point: 4.5860

>T125183 WP_023861453.1 NZ_CP040247:c2198916-2198509 [Mycobacterium avium subsp. hominissuis]
MTARPAAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAAR
MWARLRIHLAEAGRRMRANDLWIAAIAASRGLPVVTQDDDFAALDGAANLAIIRV

Download         Length: 408 bp

>T125183 NZ_CP040247:c2198916-2198509 [Mycobacterium avium subsp. hominissuis]
ATGACTGCAAGGCCGGCGGCCGGGGTGCTCGACACCTCGGTGTTCATCGCGTCCGAAAGCGGACGGCACCTGGACGAGGC
GCGAATCCCCGACGAGGTAGCCACCACCGTCATCACCCTTGCCGAACTTCACGCCGGCGTATTAGCCGCGACGACGTCCG
ACGTTCGGGCGCAACGCCTCGCAACGCTGGAATCGATAGCGGATATGGAAATGTTGCCAGTCGACGACGACGCAGCCCGC
ATGTGGGCAAGGTTGCGGATCCACCTAGCCGAGGCTGGACGGCGGATGCGGGCTAATGATCTGTGGATCGCGGCGATCGC
GGCATCGCGGGGACTGCCCGTCGTCACCCAGGATGACGACTTCGCCGCACTCGACGGCGCGGCGAACCTGGCGATTATTC
GGGTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9608.98 Da        Isoelectric Point: 11.7137

>AT125183 WP_033719712.1 NZ_CP040247:c2199173-2198913 [Mycobacterium avium subsp. hominissuis]
MSEVASRELRNDTAGVLRRVREGEDVTITINGRAVAMLTALRPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT125183 NZ_CP040247:c2199173-2198913 [Mycobacterium avium subsp. hominissuis]
ATGTCTGAAGTGGCGTCTCGCGAGCTGCGCAACGATACGGCGGGGGTACTGCGGCGCGTGCGGGAAGGGGAGGACGTCAC
CATCACCATCAACGGCCGAGCCGTCGCGATGCTGACCGCGCTGCGGCCGCAGCGACGGCGGTGGCTGAGCAAGGCGGAGT
TGCTGTCGCGCTTGCGCCGCGCGCAAGCCGATCCCGGGCTACGCCAAGACCTCGCAACCCTTGCAGGCGACACCACTGAG
GACCTCGGTCCGATCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2ZII2

Antitoxin

Source ID Structure
AlphaFold DB A0A2A2ZI58

References