Detailed information of TA system TA125181

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 618794..619358
• Replicon: chromosome
• Accession: NZ_CP040247
• Organism: Mycobacterium avium subsp. hominissuis strain 101034

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: X7VBD8
• Locus tag: FCV16_RS03380
• Protein ID: WP_003875391.1
• Coordinates: 618987..619358 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FCV16_RS03375
• Protein ID: WP_011724021.1
• Coordinates: 618794..619000 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCV16_RS03355	614233..614457	-	225	Protein_585	transposase	-
FCV16_RS03360	614501..616444	-	1944	WP_007172497.1	tyrosine-type recombinase/integrase	-
FCV16_RS03365	616441..617489	-	1049	Protein_587	tyrosine-type recombinase/integrase	-
FCV16_RS03370	617623..618615	-	993	Protein_588	IS256-like element IS1311 family transposase	-
FCV16_RS03375	618794..619000	+	207	WP_011724021.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FCV16_RS03380	618987..619358	+	372	WP_003875391.1	type II toxin-antitoxin system VapC family toxin	Toxin
FCV16_RS03385	619458..619898	+	441	WP_003875392.1	nitroreductase family deazaflavin-dependent oxidoreductase	-
FCV16_RS03390	619964..620644	-	681	WP_137987618.1	SDR family oxidoreductase	-
FCV16_RS03395	620613..620951	-	339	WP_062887574.1	DUF3024 domain-containing protein	-
FCV16_RS03400	620956..621534	-	579	WP_062895398.1	hypothetical protein	-
FCV16_RS03405	621580..622370	-	791	Protein_595	ATP-binding protein	-
FCV16_RS03410	622367..623952	-	1586	Protein_596	IS21 family transposase	-
FCV16_RS03415	624164..624346	-	183	Protein_597	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	613109..623991	10882

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13770.14 Da
• Isoelectric Point: 6.6003

>T125181 WP_003875391.1 NZ_CP040247:618987-619358 [Mycobacterium avium subsp. hominissuis]
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVECHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL

Nucleotide

• Length: 372 bp

>T125181 NZ_CP040247:618987-619358 [Mycobacterium avium subsp. hominissuis]
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGCTGACGCATGCGGAGGTCCTTCATCTCGTCGAATGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTTGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7261.25 Da
• Isoelectric Point: 11.0634

>AT125181 WP_011724021.1 NZ_CP040247:618794-619000 [Mycobacterium avium subsp. hominissuis]
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRTPADDSR

Nucleotide

• Length: 207 bp

>AT125181 NZ_CP040247:618794-619000 [Mycobacterium avium subsp. hominissuis]
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGACACCCGCCGATGATTCTCGTTGA

Structures

Toxin

• AlphaFold DB: A0A0E2WB37