125179

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 221739..222422 Replicon chromosome
Accession NZ_CP040247
Organism Mycobacterium avium subsp. hominissuis strain 101034

Toxin (Protein)


Gene name vapC Uniprot ID D5PEA4
Locus tag FCV16_RS01390 Protein ID WP_007168487.1
Coordinates 221739..222146 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X1XBB9
Locus tag FCV16_RS01395 Protein ID WP_033711258.1
Coordinates 222150..222422 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCV16_RS01370 217417..219005 - 1589 Protein_200 IS21 family transposase -
FCV16_RS01380 221011..221316 - 306 WP_007168485.1 hypothetical protein -
FCV16_RS01385 221377..221718 - 342 WP_007168486.1 hypothetical protein -
FCV16_RS01390 221739..222146 - 408 WP_007168487.1 type II toxin-antitoxin system VapC family toxin Toxin
FCV16_RS01395 222150..222422 - 273 WP_033711258.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FCV16_RS01400 222912..223130 - 219 Protein_205 transposase -
FCV16_RS01405 223177..225120 - 1944 Protein_206 tyrosine-type recombinase/integrase -
FCV16_RS01410 225117..226165 - 1049 Protein_207 tyrosine-type recombinase/integrase -
FCV16_RS01415 226282..227296 - 1015 Protein_208 IS256-like element IS1511 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 226234..226938 704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14464.55 Da        Isoelectric Point: 4.6697

>T125179 WP_007168487.1 NZ_CP040247:c222146-221739 [Mycobacterium avium subsp. hominissuis]
VIYLDTSALVKLIRIEVESDALADWLDERTETRWITSALAEVELPRAIRAVAPNGLSAVPSVLARLDRFEIDQVIRATAA
AYPDPALRSLDAIHLATAQIAASTAPLTAMVAYDSRLSDAARALGITIVTPGRNS

Download         Length: 408 bp

>T125179 NZ_CP040247:c222146-221739 [Mycobacterium avium subsp. hominissuis]
GTGATCTACCTGGATACCTCGGCTCTGGTCAAGCTGATCCGGATCGAAGTCGAATCTGATGCTCTAGCTGACTGGCTCGA
TGAACGCACCGAAACACGTTGGATAACATCTGCCTTGGCTGAAGTGGAGCTCCCCAGAGCCATCCGCGCAGTCGCCCCAA
ATGGCTTATCTGCTGTCCCCTCTGTGCTGGCCAGACTGGATCGGTTCGAAATCGACCAGGTCATCCGCGCCACCGCGGCC
GCCTACCCCGATCCGGCGCTGCGCTCGCTCGATGCGATACACCTGGCCACCGCTCAAATCGCCGCATCCACAGCACCATT
GACCGCCATGGTCGCCTATGACAGTCGACTCAGCGACGCCGCCCGTGCCCTCGGGATAACGATTGTCACACCTGGAAGAA
ACTCATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9764.35 Da        Isoelectric Point: 8.7382

>AT125179 WP_033711258.1 NZ_CP040247:c222422-222150 [Mycobacterium avium subsp. hominissuis]
MSEVPLRMLNQETAKVLARVKRGEEITLTERGEVIARIIPATAGPLDALITAGRVQPATLAGPAPRPTVPMHDNLDAGAL
LQRLRAEERY

Download         Length: 273 bp

>AT125179 NZ_CP040247:c222422-222150 [Mycobacterium avium subsp. hominissuis]
ATGAGTGAAGTACCTCTCCGAATGCTCAACCAAGAGACGGCAAAGGTCTTGGCCCGCGTCAAGCGTGGCGAAGAGATCAC
GCTTACTGAGCGCGGGGAAGTCATCGCCCGAATAATCCCCGCTACCGCCGGCCCACTGGATGCGTTGATCACTGCCGGCA
GAGTGCAACCGGCGACGCTGGCCGGCCCAGCCCCGCGGCCGACCGTTCCGATGCACGACAATCTCGACGCCGGCGCGCTA
TTGCAACGTCTGCGCGCCGAGGAAAGGTATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XAJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XBB9

References