125178

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 168283..168950 Replicon chromosome
Accession NZ_CP040247
Organism Mycobacterium avium subsp. hominissuis strain 101034

Toxin (Protein)


Gene name vapC Uniprot ID D5PE24
Locus tag FCV16_RS01140 Protein ID WP_007168407.1
Coordinates 168558..168950 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5PE23
Locus tag FCV16_RS01135 Protein ID WP_007168406.1
Coordinates 168283..168558 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCV16_RS01110 164356..165567 - 1212 Protein_149 ISL3 family transposase -
FCV16_RS01115 165706..166329 - 624 Protein_150 DDE-type integrase/transposase/recombinase -
FCV16_RS01120 166332..166421 - 90 Protein_151 SDR family oxidoreductase -
FCV16_RS01125 166474..167177 - 704 Protein_152 histidine phosphatase family protein -
FCV16_RS01130 167260..168131 + 872 Protein_153 MaoC family dehydratase N-terminal domain-containing protein -
FCV16_RS01135 168283..168558 + 276 WP_007168406.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FCV16_RS01140 168558..168950 + 393 WP_007168407.1 type II toxin-antitoxin system VapC family toxin Toxin
FCV16_RS01145 169098..170257 - 1160 Protein_156 trehalose-phosphatase -
FCV16_RS01150 170299..171635 - 1337 Protein_157 DUF1298 domain-containing protein -
FCV16_RS01155 171899..172021 - 123 Protein_158 IS1595 family transposase -
FCV16_RS01160 172357..173691 + 1335 Protein_159 IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14305.73 Da        Isoelectric Point: 10.5032

>T125178 WP_007168407.1 NZ_CP040247:168558-168950 [Mycobacterium avium subsp. hominissuis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Download         Length: 393 bp

>T125178 NZ_CP040247:168558-168950 [Mycobacterium avium subsp. hominissuis]
ATGGCGGCCATCTACCTGGACTCGTCCGCAATCGTCAAGCTTGCAGTTCGTGAGCCAGAGTCGGATGCGCTGCGTCGCTA
CCTTCGCACCCGGCTGCCGCGGGTGTCGAGTGCCCTTGCGCGGACGGAGGTCATGCGGGCTCTGCTCCACAAGGGTGAAT
CAGCCCGAAGAGCCGGACGCCGGGCGCTCGCGAGCCTAGACCTACTACGCATCGACAACCGATTGCTCGATCTTGCTGGT
GGGCTGCTGCCAATCGAGCTACGCACCCTCGATGCAATTCACCTGGCGACTGCCCAGCGGCTCGGCATGGATCTTGGCCG
GTTGTGCACTTACGACGACCGCATGCGCGACGCCGCCGAGGCGCTCGGCATGGCAGTGATTGCCCCGTCTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10150.63 Da        Isoelectric Point: 5.1881

>AT125178 WP_007168406.1 NZ_CP040247:168283-168558 [Mycobacterium avium subsp. hominissuis]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Download         Length: 276 bp

>AT125178 NZ_CP040247:168283-168558 [Mycobacterium avium subsp. hominissuis]
ATGTCTACGGTGGGCGTTCGTGAGCTGCGGCAGCGGGCCAGCGAACTCCTCCGTCGGGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGTGGTCGGCCTATCGCCCTTCTCTCGCCGATGCCGGAGGGCGGTCCGTACCAGCAGATGCTGGCAAGCG
GCGGGATCGAACGTGCGACGCTTGACTTTGATGACCTTCCCGAGCCGGTCCGACTCAAAACGGGTATCGAGCTGCCGTCC
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XV84

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XUZ3

References