Detailed information of TA system TA125177

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 7464474..7465108
• Replicon: chromosome
• Accession: NZ_CP040244
• Organism: Streptomyces exfoliatus strain A1013Y

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FDM97_RS34730
• Protein ID: WP_137994422.1
• Coordinates: 7464686..7465108 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FDM97_RS34725
• Protein ID: WP_079428878.1
• Coordinates: 7464474..7464689 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDM97_RS34720	7461982..7464408	+	2427	WP_137994421.1	helicase-associated domain-containing protein	-
FDM97_RS34725	7464474..7464689	+	216	WP_079428878.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FDM97_RS34730	7464686..7465108	+	423	WP_137994422.1	PIN domain nuclease	Toxin
FDM97_RS34735	7465745..7466056	-	312	Protein_6787	hypothetical protein	-
FDM97_RS34740	7465992..7468262	+	2271	WP_137994423.1	VCBS repeat-containing protein	-
FDM97_RS34745	7468428..7469627	+	1200	WP_137994424.1	protein kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-124)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-49)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15385.33 Da
• Isoelectric Point: 4.7221

>T125177 WP_137994422.1 NZ_CP040244:7464686-7465108 [Streptomyces exfoliatus]
VNAALYLIDTSALARFMRGDAEQYGWDQAAAAGLIATCPITELEFFYSARSAADRARGIEDIRLIFGWVPVDDRAYDRAW
QVQEALTKQGKHRSAGAVDLVVAATAELQGLTLLHCDHDFECIAAVTGQPLQWYGPEGRK

Nucleotide

• Length: 423 bp

>T125177 NZ_CP040244:7464686-7465108 [Streptomyces exfoliatus]
GTGAATGCCGCGCTCTACCTGATCGACACCAGCGCCCTCGCCCGATTCATGCGGGGCGACGCGGAGCAGTACGGCTGGGA
CCAGGCAGCAGCAGCCGGCCTCATCGCCACGTGCCCCATCACGGAGCTGGAGTTCTTCTACAGCGCCCGATCGGCCGCCG
ACCGGGCACGCGGCATCGAGGACATACGGCTGATCTTCGGCTGGGTCCCGGTCGACGACCGCGCCTACGACCGCGCCTGG
CAGGTCCAGGAAGCCCTCACCAAACAGGGCAAGCACCGCAGCGCCGGTGCGGTGGATCTCGTCGTCGCCGCGACCGCCGA
GTTGCAGGGACTGACACTCCTGCACTGCGACCACGACTTCGAGTGCATCGCCGCAGTAACCGGCCAACCCCTCCAGTGGT
ACGGCCCCGAGGGGCGTAAGTAG

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8051.13 Da
• Isoelectric Point: 8.6590

>AT125177 WP_079428878.1 NZ_CP040244:7464474-7464689 [Streptomyces exfoliatus]
MSRTVIDLDDELVADVAKALGTSTKKETVNTALREVLENRRRALALTRLRAAADEGAFDLTLFEDKRNYRR

Nucleotide

• Length: 216 bp

>AT125177 NZ_CP040244:7464474-7464689 [Streptomyces exfoliatus]
ATGAGCCGGACAGTGATCGACCTCGATGACGAGCTGGTGGCAGACGTAGCCAAAGCCCTGGGCACCAGTACCAAGAAGGA
GACGGTCAACACAGCCTTGCGCGAGGTACTGGAGAACAGGCGGCGGGCGCTGGCCCTGACCCGCCTGCGCGCCGCGGCCG
ACGAAGGCGCGTTCGATCTGACGCTCTTCGAGGACAAGCGGAACTACCGACGGTGA