Detailed information of TA system TA125176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 7199001..7199527
• Replicon: chromosome
• Accession: NZ_CP040244
• Organism: Streptomyces exfoliatus strain A1013Y

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FDM97_RS33510
• Protein ID: WP_137994233.1
• Coordinates: 7199273..7199527 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: FDM97_RS33505
• Protein ID: WP_137994232.1
• Coordinates: 7199001..7199276 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDM97_RS33500	7195614..7198742	+	3129	WP_137994231.1	VCBS repeat-containing protein	-
FDM97_RS33505	7199001..7199276	+	276	WP_137994232.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FDM97_RS33510	7199273..7199527	+	255	WP_137994233.1	Txe/YoeB family addiction module toxin	Toxin
FDM97_RS33515	7199660..7200886	+	1227	WP_175439449.1	MFS transporter	-
FDM97_RS33520	7200890..7201174	-	285	WP_137994235.1	DUF4031 domain-containing protein	-
FDM97_RS33525	7201171..7201527	-	357	WP_137994236.1	hypothetical protein	-
FDM97_RS33530	7201603..7202532	+	930	WP_137994237.1	MurR/RpiR family transcriptional regulator	-
FDM97_RS33535	7202551..7203492	+	942	WP_137994238.1	N-acetylmuramic acid 6-phosphate etherase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10077.50 Da
• Isoelectric Point: 10.1925

>T125176 WP_137994233.1 NZ_CP040244:7199273-7199527 [Streptomyces exfoliatus]
VKVVFSGRAWDQYTYWTTADPKVLKRINRLIKEIQRTPFEGAGKPEPLKETLSGWWSRRITDEHRLVYRVRDEAVEIAQA
RYHY

Nucleotide

• Length: 255 bp

>T125176 NZ_CP040244:7199273-7199527 [Streptomyces exfoliatus]
GTGAAGGTCGTCTTCTCCGGCCGGGCGTGGGACCAGTACACCTACTGGACAACAGCCGACCCGAAGGTCCTCAAGAGGAT
CAACCGTCTGATCAAGGAAATCCAGCGAACGCCGTTCGAGGGCGCCGGCAAGCCGGAACCGCTCAAGGAAACCCTCTCAG
GATGGTGGTCCCGCCGGATCACCGACGAGCACCGCCTGGTGTACCGCGTGCGGGATGAGGCCGTGGAGATCGCCCAGGCC
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10287.35 Da
• Isoelectric Point: 4.3016

>AT125176 WP_137994232.1 NZ_CP040244:7199001-7199276 [Streptomyces exfoliatus]
VSISANEARQRFYPLIKQVNEDHQPIEVTSREHGDIVIMSAEDFRSWQETVYLLRSPRNAQILMESIAELDAGRGQAREL
IDTDDTEGSAA

Nucleotide

• Length: 276 bp

>AT125176 NZ_CP040244:7199001-7199276 [Streptomyces exfoliatus]
GTGTCGATTTCGGCGAACGAGGCCCGCCAGCGTTTCTACCCGCTGATCAAGCAGGTCAACGAAGATCACCAACCGATAGA
GGTCACCTCCCGCGAGCACGGGGACATCGTCATCATGTCCGCCGAGGACTTCCGCTCCTGGCAGGAGACGGTGTATCTCC
TGCGCTCGCCGCGCAACGCACAGATCCTCATGGAGTCCATCGCAGAGCTGGACGCCGGCCGCGGCCAGGCCAGGGAACTG
ATCGACACAGACGACACCGAAGGGTCCGCCGCGTGA