Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1397469..1398091 Replicon chromosome
Accession NZ_CP040243
Organism Glaesserella parasuis strain HPS-1

Toxin (Protein)


Gene name hicA Uniprot ID A0A836YYE8
Locus tag FEF05_RS06975 Protein ID WP_005715063.1
Coordinates 1397469..1397651 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A836MEP4
Locus tag FEF05_RS06980 Protein ID WP_021113997.1
Coordinates 1397678..1398091 (+) Length 138 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEF05_RS06925 1392647..1393099 - 453 WP_044008920.1 terminase small subunit -
FEF05_RS06930 1393268..1393417 - 150 WP_021110724.1 hypothetical protein -
FEF05_RS06935 1393446..1393790 - 345 WP_187765027.1 DUF2570 family protein -
FEF05_RS06940 1393763..1394308 - 546 WP_149350966.1 lysozyme -
FEF05_RS06945 1394283..1394582 - 300 WP_187765028.1 hypothetical protein -
FEF05_RS06950 1394696..1395259 + 564 WP_012621835.1 hypothetical protein -
FEF05_RS06955 1395605..1395790 + 186 WP_005714898.1 type II toxin-antitoxin system HicA family toxin -
FEF05_RS06960 1395820..1396257 + 438 WP_005714900.1 type II toxin-antitoxin system HicB family antitoxin -
FEF05_RS06965 1396279..1396656 - 378 WP_021109621.1 ECF sigma factor family protein -
FEF05_RS06970 1396653..1397222 - 570 WP_149350967.1 recombination protein NinG -
FEF05_RS11885 1397194..1397370 - 177 WP_187765029.1 hypothetical protein -
FEF05_RS06975 1397469..1397651 + 183 WP_005715063.1 type II toxin-antitoxin system HicA family toxin Toxin
FEF05_RS06980 1397678..1398091 + 414 WP_021113997.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FEF05_RS06985 1398125..1398553 - 429 WP_149350968.1 recombination protein NinB -
FEF05_RS06990 1398615..1399970 - 1356 WP_149350969.1 AAA family ATPase -
FEF05_RS06995 1399970..1400848 - 879 WP_021114967.1 replication protein -
FEF05_RS07000 1401069..1401326 - 258 Protein_1346 hypothetical protein -
FEF05_RS07005 1401347..1401547 - 201 WP_016527563.1 helix-turn-helix domain-containing protein -
FEF05_RS07010 1401678..1402361 + 684 WP_149350970.1 S24 family peptidase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1375844..1411411 35567


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6678.80 Da        Isoelectric Point: 10.6602

>T125173 WP_005715063.1 NZ_CP040243:1397469-1397651 [Glaesserella parasuis]
VDSKTIIKMIEADGWYLVATSGSHHQFKHPTKQGRVTVPHPKKDLKKGTELSILKQAGLK

Download         Length: 183 bp

>T125173 NZ_CP040243:1397469-1397651 [Glaesserella parasuis]
GTGGATAGCAAAACCATAATTAAAATGATTGAAGCGGACGGTTGGTACTTAGTTGCAACAAGTGGAAGCCACCATCAATT
CAAACATCCAACTAAACAAGGGCGAGTAACAGTGCCTCATCCGAAAAAGGATTTAAAAAAAGGAACTGAACTCTCAATAC
TTAAACAAGCGGGGCTAAAATAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15277.32 Da        Isoelectric Point: 4.3689

>AT125173 WP_021113997.1 NZ_CP040243:1397678-1398091 [Glaesserella parasuis]
MLYPIAIEPGDETHAYGVIVPDIPGCFSAGDTLEEAYQNVKEAIVFHLEGLVEDGEDIPLPTSIENHRNNPDFTDYGMFF
GIVDVDISHLLGKAERINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA

Download         Length: 414 bp

>AT125173 NZ_CP040243:1397678-1398091 [Glaesserella parasuis]
ATGTTATACCCAATTGCAATTGAACCAGGTGACGAAACTCACGCTTACGGCGTTATCGTGCCTGATATTCCAGGGTGCTT
CTCTGCTGGCGATACCCTCGAAGAAGCATATCAAAATGTCAAAGAAGCCATCGTGTTCCACCTTGAAGGCTTAGTTGAAG
ATGGAGAAGATATTCCATTACCAACGAGTATCGAAAATCACCGTAACAACCCTGATTTTACCGATTACGGTATGTTCTTT
GGGATTGTTGATGTTGATATTAGCCATTTACTCGGAAAAGCCGAACGCATCAACATCACCCTCCCTAGCTATCTCATCAA
ACGCATTGATGATTTTGTTGCGGTTCACAAAGAGTATAAAAACCGTAGCAACTTCTTAGCTAAAATCGCAGCGGATAAAA
TCTTAACCGCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A836YYE8


Antitoxin

Source ID Structure
AlphaFold DB A0A836MEP4

References