Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 493484..495171 Replicon chromosome
Accession NZ_CP040243
Organism Glaesserella parasuis strain HPS-1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FEF05_RS02605 Protein ID WP_149350684.1
Coordinates 493484..494827 (+) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FEF05_RS02610 Protein ID WP_005713145.1
Coordinates 494827..495171 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEF05_RS02580 488487..490664 - 2178 WP_149350683.1 bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL -
FEF05_RS02585 490814..491755 - 942 WP_015940030.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
FEF05_RS02590 491838..492251 + 414 WP_005713136.1 DNA polymerase III subunit psi -
FEF05_RS02595 492253..492693 + 441 WP_016528419.1 M23 family metallopeptidase -
FEF05_RS02600 492935..493372 + 438 WP_021110342.1 ribosomal protein S18-alanine N-acetyltransferase -
FEF05_RS02605 493484..494827 + 1344 WP_149350684.1 type II toxin-antitoxin system HipA family toxin Toxin
FEF05_RS02610 494827..495171 + 345 WP_005713145.1 helix-turn-helix domain-containing protein Antitoxin
FEF05_RS02615 495200..496525 + 1326 WP_149350685.1 ATP-dependent RNA helicase SrmB -
FEF05_RS02620 496643..497275 + 633 WP_149350686.1 lipoprotein insertase outer membrane protein LolB -
FEF05_RS02625 497277..498122 + 846 WP_149350687.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
FEF05_RS02630 498150..499100 + 951 WP_005713153.1 ribose-phosphate pyrophosphokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(161-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 51071.00 Da        Isoelectric Point: 5.1100

>T125168 WP_149350684.1 NZ_CP040243:493484-494827 [Glaesserella parasuis]
MQIEPLTLQAYIADRWQDIAILTFQADYSLNDFSYLYDLAEILSDNDKAVSFNYPVEFFPYRSVSGWFAFLYDIVPSGAS
RRYWLQKLDIAHLPTAQQNYLLLKQGTIAPVGHLRVKQAVSSFIENEPPRLFEIDDVINRQADFLEYANQRGAMAGGATG
AGGEAPKLLLRQTATQQVWIDNLQQGDAADDFYLVKFPRGKRSAIDCDILRAEFHYYHELASMGFDTIDTTKMRLEEGER
YPSLWLPRFDVYRNEQGKMARYAVESVYAMLEKGAGSLLDHEKVIRQLIAKIENSHLVETGMAFDKQAFVIEWVRRDLLN
IAFGNSDNHGRNTAFLRNQNRIWLAPIYDFAPMKADPEGIPRTTMWDSKSHPALELGGEYRFDLIAERLDDLCSADKLLD
ALRQTAQQLAGLKARLEARGVPTAILTYPSISLDYLPEKLQRWQLLS

Download         Length: 1344 bp

>T125168 NZ_CP040243:493484-494827 [Glaesserella parasuis]
ATGCAAATCGAACCGCTTACACTTCAGGCCTATATTGCTGATCGTTGGCAGGATATTGCTATTTTGACCTTTCAGGCTGA
TTATAGCCTCAATGATTTTAGCTATCTCTATGATTTAGCAGAGATTTTAAGTGATAATGATAAGGCAGTTTCATTTAACT
ATCCTGTGGAGTTTTTCCCATACCGTAGTGTATCGGGCTGGTTTGCATTTTTATATGATATAGTTCCTTCTGGGGCAAGT
CGGCGTTATTGGTTGCAAAAACTTGATATTGCTCATTTGCCGACAGCTCAACAAAACTATTTGTTATTAAAACAAGGTAC
GATTGCACCTGTCGGGCATTTACGAGTGAAGCAAGCGGTCAGTTCTTTTATCGAAAATGAACCCCCTCGCTTATTTGAAA
TAGATGATGTTATCAATCGCCAAGCTGATTTTTTAGAATATGCTAATCAGCGTGGGGCAATGGCTGGCGGTGCAACGGGG
GCTGGTGGCGAAGCGCCGAAATTATTGCTACGCCAAACAGCCACTCAGCAAGTTTGGATTGATAATCTACAACAAGGTGA
CGCTGCCGACGATTTCTATTTAGTCAAGTTTCCGCGTGGAAAACGCAGTGCAATAGATTGCGACATATTGAGAGCTGAAT
TTCACTATTACCACGAATTAGCCTCAATGGGTTTTGATACCATTGATACGACAAAAATGCGGTTGGAAGAGGGCGAACGT
TACCCGTCGTTATGGTTACCTCGCTTTGATGTTTATCGTAATGAACAGGGGAAAATGGCTCGTTATGCCGTTGAATCTGT
TTATGCTATGTTAGAAAAAGGGGCTGGCTCTTTGCTGGATCACGAAAAGGTTATTCGTCAGTTGATTGCCAAAATTGAAA
ATTCTCACCTAGTTGAAACAGGAATGGCTTTTGATAAACAGGCTTTTGTGATCGAGTGGGTAAGGCGAGATTTATTGAAT
ATCGCCTTTGGAAATAGCGATAATCACGGGCGAAATACCGCTTTCTTACGCAATCAAAATCGTATTTGGCTTGCTCCAAT
TTATGATTTTGCCCCAATGAAAGCGGATCCTGAAGGCATTCCTCGTACGACAATGTGGGATAGTAAAAGTCACCCTGCAT
TAGAATTAGGCGGTGAATATCGTTTTGATCTGATTGCAGAACGGCTTGATGATTTGTGTTCAGCCGACAAGTTATTAGAT
GCTTTGCGTCAAACGGCTCAACAGCTCGCTGGGCTTAAAGCACGTTTAGAAGCAAGAGGCGTTCCAACGGCAATTTTGAC
GTACCCCTCAATCAGCTTGGACTATTTACCTGAAAAATTACAACGTTGGCAATTATTATCATAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13207.48 Da        Isoelectric Point: 10.2782

>AT125168 WP_005713145.1 NZ_CP040243:494827-495171 [Glaesserella parasuis]
MEEIKQARASKSKKTLDIYQRATVRDEIARKLLLNEMSLGQALKYLRLHLLAMKQERYAEIVKVSRKTLSDLENDKGNYS
IDIINQVLRPFELQLGVVPINKTLLRQVLNEQAV

Download         Length: 345 bp

>AT125168 NZ_CP040243:494827-495171 [Glaesserella parasuis]
ATGGAAGAGATCAAACAGGCTAGAGCCTCTAAAAGTAAAAAAACGTTAGATATTTATCAGCGAGCGACTGTGCGAGACGA
AATTGCTCGTAAGCTATTGCTCAATGAGATGAGTTTAGGGCAGGCGTTGAAATATCTACGTTTACATCTACTGGCAATGA
AACAAGAGCGTTATGCGGAGATTGTCAAAGTTTCTCGCAAAACGTTATCTGATTTAGAAAATGATAAGGGAAATTACAGT
ATTGATATTATCAATCAGGTGTTACGCCCCTTTGAATTACAGCTCGGCGTGGTGCCAATAAACAAAACATTACTCAGACA
AGTTTTAAATGAACAAGCGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References