Detailed information of TA system TA125167

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 3298..4216
• Replicon: plasmid pCcS9_3
• Accession: NZ_CP040242
• Organism: Campylobacter coli strain S9

Toxin (Protein)

• Gene name: Fic
• Uniprot ID: -
• Locus tag: FD987_RS08895
• Protein ID: WP_138013359.1
• Coordinates: 3533..4216 (+)
• Length: 228 a.a.

Antitoxin (Protein)

• Gene name: Fti
• Uniprot ID: A0A0Q2TTN4
• Locus tag: FD987_RS08890
• Protein ID: WP_002804094.1
• Coordinates: 3298..3540 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD987_RS08880	651..2474	+	1824	WP_052778218.1	type IV secretory system conjugative DNA transfer family protein	-
FD987_RS08885	2485..3204	+	720	WP_057030772.1	conjugal transfer protein TraL	-
FD987_RS08890	3298..3540	+	243	WP_002804094.1	hypothetical protein	Antitoxin
FD987_RS08895	3533..4216	+	684	WP_138013359.1	Fic family protein	Toxin
FD987_RS08900	4221..4688	+	468	WP_138013360.1	signal peptidase I	-
FD987_RS08905	4753..5148	+	396	WP_004294083.1	conjugal transfer protein TraM	-
FD987_RS08910	5240..5926	+	687	WP_002791558.1	AAA family ATPase	-
FD987_RS08915	5929..6153	+	225	WP_002790621.1	hypothetical protein	-
FD987_RS08925	6394..8550	-	2157	WP_002838514.1	relaxase/mobilization nuclease domain-containing protein	-
FD987_RS08930	8513..8896	-	384	WP_052778221.1	DNA transfer protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..25776	25776

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (60-169)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 228 a.a.
• Molecular weight: 26024.19 Da
• Isoelectric Point: 10.0331

>T125167 WP_138013359.1 NZ_CP040242:3533-4216 [Campylobacter coli]
MIDKVLKFLDDGIPKNDFDRQLLASNLVGATNLIELNKKERIITLQAAKKLELNPIKGNFDYQHLKDIHKALFEDVYTWA
GQDRMQMGLKEKFAKYAPNGAIINFVPGKELDKYSKIIFDELAKNNYLKNSKDLNHFAKNLAKFMGEINALHPFREGNGR
TQRIFLNELAKNAGYKLDLNLISKHKMIHACVEASQLKPGRLEALIKDNLKNFRQNLDLEQNKGISL

Nucleotide

• Length: 684 bp

>T125167 NZ_CP040242:3533-4216 [Campylobacter coli]
ATGATTGATAAAGTTTTGAAATTTTTAGATGATGGTATTCCTAAAAATGATTTTGATAGACAACTTTTAGCTTCTAATTT
AGTAGGCGCAACAAATTTAATAGAGTTAAATAAAAAAGAAAGAATAATAACTCTACAAGCCGCTAAAAAATTAGAGCTTA
ATCCAATTAAAGGCAATTTTGACTATCAACACTTAAAAGATATACATAAAGCACTTTTTGAAGATGTTTATACTTGGGCG
GGACAAGATAGAATGCAAATGGGGCTAAAAGAAAAATTTGCAAAATATGCACCCAATGGAGCAATTATTAATTTTGTTCC
TGGAAAAGAGTTAGATAAATACTCTAAAATAATTTTTGATGAACTTGCAAAAAATAATTATCTAAAAAACTCCAAAGATC
TAAATCATTTTGCAAAAAATTTAGCAAAATTTATGGGCGAAATCAATGCTTTACACCCCTTTAGAGAAGGTAACGGCAGA
ACTCAAAGAATATTTTTAAATGAATTAGCTAAAAATGCAGGTTATAAACTTGATTTAAATTTAATTTCTAAGCATAAAAT
GATACATGCTTGCGTAGAAGCTTCACAATTAAAACCTGGAAGATTGGAGGCTTTAATTAAAGACAATCTAAAAAACTTTA
GACAAAACTTAGATTTAGAGCAAAATAAAGGAATATCATTGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9452.68 Da
• Isoelectric Point: 4.3535

>AT125167 WP_002804094.1 NZ_CP040242:3298-3540 [Campylobacter coli]
MQKQYPEVHSLEESLAILKKYKDDLTKEQYEQNKSIICGFAIENMFANEEDIINLIKVDKQEKTPDEIIAEYKKEWGVND

Nucleotide

• Length: 243 bp

>AT125167 NZ_CP040242:3298-3540 [Campylobacter coli]
ATGCAAAAACAATATCCCGAAGTGCATAGCTTAGAAGAAAGCCTTGCAATACTTAAAAAATATAAAGATGATTTAACCAA
AGAGCAATATGAGCAAAATAAATCTATTATTTGTGGATTTGCTATTGAGAATATGTTTGCAAATGAAGAAGACATTATAA
ATCTCATAAAAGTAGATAAACAAGAAAAAACACCTGATGAAATAATCGCCGAATATAAAAAAGAGTGGGGTGTAAATGAT
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0Q2TTN4