Detailed information of TA system TA125163

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/PIN-RelB
• Location: 1407104..1407957
• Replicon: chromosome
• Accession: NZ_CP040235
• Organism: Bifidobacterium longum strain ZJ1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0M4MHM8
• Locus tag: FCE94_RS06415
• Protein ID: WP_060620906.1
• Coordinates: 1407104..1407595 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FCE94_RS06420
• Protein ID: WP_137658439.1
• Coordinates: 1407595..1407957 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCE94_RS06395	1402176..1403408	+	1233	WP_032742351.1	sensor histidine kinase	-
FCE94_RS06400	1403443..1404168	+	726	WP_007056206.1	response regulator transcription factor	-
FCE94_RS06405	1404208..1404849	+	642	WP_007052627.1	GNAT family N-acetyltransferase	-
FCE94_RS06410	1404939..1407044	+	2106	WP_137658438.1	DUF262 domain-containing protein	-
FCE94_RS06415	1407104..1407595	-	492	WP_060620906.1	PIN domain-containing protein	Toxin
FCE94_RS06420	1407595..1407957	-	363	WP_137658439.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FCE94_RS06425	1408102..1410801	-	2700	WP_007054466.1	aconitate hydratase AcnA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-141)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-53)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 18342.90 Da
• Isoelectric Point: 4.5590

>T125163 WP_060620906.1 NZ_CP040235:c1407595-1407104 [Bifidobacterium longum]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRREFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDRAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Nucleotide

• Length: 492 bp

>T125163 NZ_CP040235:c1407595-1407104 [Bifidobacterium longum]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTCGATACCAACGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACGTTACGTTGTTGTGCGCGTCATTGTCGCTGAAGGATA
TCGCATACCTATCATCATCGGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCGGCTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATCGTCGCTGTCGATGAGTCGACATG
TGATAGGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAATTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCGCTGGAATAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13855.95 Da
• Isoelectric Point: 5.3564

>AT125163 WP_137658439.1 NZ_CP040235:c1407957-1407595 [Bifidobacterium longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEGTDLMEGLTCKQFRDKMYDEQLDAYYNMKRAD

Nucleotide

• Length: 363 bp

>AT125163 NZ_CP040235:c1407957-1407595 [Bifidobacterium longum]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTATACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTACACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGGCACCGACCTCATGGAAGGCCTTACCTGCAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATGCGTATTACAACATGAAGAGGGCCGATTGA

Structures

Toxin

• AlphaFold DB: A0A0M4MHM8