Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 517666..518142 Replicon chromosome
Accession NZ_CP040233
Organism Staphylococcus aureus strain GD1696

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FD747_RS02540 Protein ID WP_000052076.1
Coordinates 517666..517854 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FD747_RS02545 Protein ID WP_001059690.1
Coordinates 517882..518142 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD747_RS02510 513695..514177 + 483 WP_031886402.1 hypothetical protein -
FD747_RS02515 514518..515204 + 687 WP_138765632.1 thermonuclease family protein -
FD747_RS02520 515561..515761 + 201 WP_001059082.1 cold-shock protein -
FD747_RS02525 516258..516476 - 219 WP_000005881.1 hypothetical protein -
FD747_RS02530 516537..516821 - 285 WP_001004403.1 hypothetical protein -
FD747_RS02535 516909..517478 - 570 WP_001106655.1 hypothetical protein -
FD747_RS02540 517666..517854 - 189 WP_000052076.1 hypothetical protein Toxin
FD747_RS02545 517882..518142 - 261 WP_001059690.1 hypothetical protein Antitoxin
FD747_RS02550 518484..518687 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FD747_RS02555 518684..518920 - 237 WP_000368687.1 hypothetical protein -
FD747_RS02560 519145..519726 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
FD747_RS02565 519799..520416 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
FD747_RS02570 520565..521059 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
FD747_RS02575 521458..521880 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
FD747_RS02580 522028..522744 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(37-142)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T125136 WP_000052076.1 NZ_CP040233:c517854-517666 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T125136 NZ_CP040233:c517854-517666 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT125136 WP_001059690.1 NZ_CP040233:c518142-517882 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT125136 NZ_CP040233:c518142-517882 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References