125126

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 975164..975640 Replicon chromosome
Accession NZ_CP040232
Organism Staphylococcus aureus strain GD1706

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FD746_RS04910 Protein ID WP_000052076.1
Coordinates 975164..975352 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FD746_RS04915 Protein ID WP_001059690.1
Coordinates 975380..975640 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD746_RS04880 971193..971675 + 483 WP_031886402.1 hypothetical protein -
FD746_RS04885 972016..972702 + 687 WP_001574556.1 thermonuclease family protein -
FD746_RS04890 973059..973259 + 201 WP_001059082.1 cold-shock protein -
FD746_RS04895 973756..973974 - 219 WP_000005881.1 hypothetical protein -
FD746_RS04900 974035..974319 - 285 WP_001004403.1 hypothetical protein -
FD746_RS04905 974407..974976 - 570 WP_001106655.1 hypothetical protein -
FD746_RS04910 975164..975352 - 189 WP_000052076.1 hypothetical protein Toxin
FD746_RS04915 975380..975640 - 261 WP_001059690.1 hypothetical protein Antitoxin
FD746_RS04920 975982..976185 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FD746_RS04925 976182..976418 - 237 WP_000368687.1 hypothetical protein -
FD746_RS04930 976643..977224 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
FD746_RS04935 977297..977914 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
FD746_RS04940 978063..978557 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
FD746_RS04945 978956..979378 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
FD746_RS04950 979526..980242 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 916860..976418 59558


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T125126 WP_000052076.1 NZ_CP040232:c975352-975164 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T125126 NZ_CP040232:c975352-975164 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT125126 WP_001059690.1 NZ_CP040232:c975640-975380 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT125126 NZ_CP040232:c975640-975380 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References