Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2687409..2687923 Replicon chromosome
Accession NZ_CP040230
Organism Staphylococcus aureus strain GD1108

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag FD491_RS13140 Protein ID WP_000581792.1
Coordinates 2687714..2687923 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag FD491_RS13135 Protein ID WP_000138932.1
Coordinates 2687409..2687702 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD491_RS13115 2683172..2684487 + 1316 Protein_2547 ISL3 family transposase -
FD491_RS13120 2684484..2684804 - 321 WP_001825748.1 hypothetical protein -
FD491_RS13125 2685084..2685731 - 648 WP_001187614.1 HD domain-containing protein -
FD491_RS13130 2685759..2687243 - 1485 WP_000571550.1 cardiolipin synthase -
FD491_RS13135 2687409..2687702 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
FD491_RS13140 2687714..2687923 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
FD491_RS13145 2688051..2688188 + 138 WP_000828354.1 hypothetical protein -
FD491_RS13150 2688452..2689654 - 1203 WP_001109939.1 rod shape-determining protein RodA -
FD491_RS13155 2689972..2691042 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
FD491_RS13160 2691057..2692412 + 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T125117 WP_000581792.1 NZ_CP040230:2687714-2687923 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T125117 NZ_CP040230:2687714-2687923 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT125117 WP_000138932.1 NZ_CP040230:2687409-2687702 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT125117 NZ_CP040230:2687409-2687702 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References