125109

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1137327..1137803 Replicon chromosome
Accession NZ_CP040230
Organism Staphylococcus aureus strain GD1108

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FD491_RS05590 Protein ID WP_000052076.1
Coordinates 1137615..1137803 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FD491_RS05585 Protein ID WP_001059690.1
Coordinates 1137327..1137587 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD491_RS05550 1132725..1133441 - 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -
FD491_RS05555 1133589..1134011 + 423 WP_000974452.1 organic hydroperoxide resistance protein -
FD491_RS05560 1134410..1134904 + 495 WP_000569881.1 GNAT family N-acetyltransferase -
FD491_RS05565 1135053..1135670 + 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
FD491_RS05570 1135743..1136324 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
FD491_RS05575 1136549..1136785 + 237 WP_000368687.1 hypothetical protein -
FD491_RS05580 1136782..1136985 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FD491_RS05585 1137327..1137587 + 261 WP_001059690.1 hypothetical protein Antitoxin
FD491_RS05590 1137615..1137803 + 189 WP_000052076.1 hypothetical protein Toxin
FD491_RS05595 1137991..1138560 + 570 WP_001106655.1 hypothetical protein -
FD491_RS05600 1138648..1138932 + 285 WP_001004403.1 hypothetical protein -
FD491_RS05605 1138993..1139211 + 219 WP_000005881.1 hypothetical protein -
FD491_RS05610 1139708..1139908 - 201 WP_001059082.1 cold-shock protein -
FD491_RS05615 1140265..1140951 - 687 WP_001574556.1 thermonuclease family protein -
FD491_RS05620 1141292..1141774 - 483 WP_000824490.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 1135743..1195655 59912


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-150)

Antitoxin

LOG family

(158-286)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T125109 WP_000052076.1 NZ_CP040230:1137615-1137803 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T125109 NZ_CP040230:1137615-1137803 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT125109 WP_001059690.1 NZ_CP040230:1137327-1137587 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT125109 NZ_CP040230:1137327-1137587 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References