Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2078439..2078953 Replicon chromosome
Accession NZ_CP040229
Organism Staphylococcus aureus strain GD487

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag FD482_RS10215 Protein ID WP_000581792.1
Coordinates 2078439..2078648 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag FD482_RS10220 Protein ID WP_000138932.1
Coordinates 2078660..2078953 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD482_RS10195 2073950..2075305 - 1356 WP_138767008.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
FD482_RS10200 2075320..2076390 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
FD482_RS10205 2076708..2077910 + 1203 WP_001109939.1 rod shape-determining protein RodA -
FD482_RS10210 2078174..2078311 - 138 WP_000828354.1 hypothetical protein -
FD482_RS10215 2078439..2078648 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
FD482_RS10220 2078660..2078953 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
FD482_RS10225 2079119..2080603 + 1485 WP_000571550.1 cardiolipin synthase -
FD482_RS10230 2080631..2081264 + 634 Protein_1976 HD domain-containing protein -
FD482_RS10235 2081544..2081864 + 321 WP_001825748.1 hypothetical protein -
FD482_RS10240 2081861..2083176 - 1316 Protein_1978 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T125100 WP_000581792.1 NZ_CP040229:c2078648-2078439 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T125100 NZ_CP040229:c2078648-2078439 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT125100 WP_000138932.1 NZ_CP040229:c2078953-2078660 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT125100 NZ_CP040229:c2078953-2078660 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References