Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 807303..807779 Replicon chromosome
Accession NZ_CP040229
Organism Staphylococcus aureus strain GD487

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FD482_RS03755 Protein ID WP_000052076.1
Coordinates 807303..807491 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FD482_RS03760 Protein ID WP_001059690.1
Coordinates 807519..807779 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD482_RS03725 803332..803814 + 483 WP_000824490.1 hypothetical protein -
FD482_RS03730 804155..804841 + 687 WP_001574556.1 thermonuclease family protein -
FD482_RS03735 805198..805398 + 201 WP_001059082.1 cold-shock protein -
FD482_RS03740 805895..806113 - 219 WP_000005881.1 hypothetical protein -
FD482_RS03745 806174..806458 - 285 WP_001004403.1 hypothetical protein -
FD482_RS03750 806546..807115 - 570 WP_001106655.1 hypothetical protein -
FD482_RS03755 807303..807491 - 189 WP_000052076.1 hypothetical protein Toxin
FD482_RS03760 807519..807779 - 261 WP_001059690.1 hypothetical protein Antitoxin
FD482_RS03765 808121..808324 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FD482_RS03770 808321..808557 - 237 WP_138766943.1 hypothetical protein -
FD482_RS03775 808782..809363 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
FD482_RS03780 809436..810053 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
FD482_RS03785 810202..810696 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
FD482_RS03790 811095..811517 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
FD482_RS03795 811665..812381 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(11-155)

Antitoxin

LOG family

(160-289)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T125093 WP_000052076.1 NZ_CP040229:c807491-807303 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T125093 NZ_CP040229:c807491-807303 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT125093 WP_001059690.1 NZ_CP040229:c807779-807519 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT125093 NZ_CP040229:c807779-807519 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References