Detailed information of TA system TA125090

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 5084347..5085119
• Replicon: chromosome
• Accession: NZ_CP040183
• Organism: Raoultella planticola strain Rp_CZ180511

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: FDZ05_RS24150
• Protein ID: WP_047724668.1
• Coordinates: 5084347..5084736 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: FDZ05_RS24155
• Protein ID: WP_171972752.1
• Coordinates: 5084793..5085119 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDZ05_RS24130	5079659..5081278	+	1620	WP_180888745.1	helicase/relaxase domain-containing protein	-
FDZ05_RS24135	5081268..5082194	+	927	WP_180888746.1	site-specific integrase	-
FDZ05_RS24140	5082474..5083271	-	798	WP_047724663.1	helix-turn-helix transcriptional regulator	-
FDZ05_RS24145	5083415..5084260	-	846	WP_047724666.1	DUF4942 domain-containing protein	-
FDZ05_RS24150	5084347..5084736	-	390	WP_047724668.1	TA system toxin CbtA family protein	Toxin
FDZ05_RS24155	5084793..5085119	-	327	WP_171972752.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FDZ05_RS24160	5085177..5085398	-	222	WP_047724679.1	DUF987 domain-containing protein	-
FDZ05_RS24165	5085412..5085891	-	480	WP_047724681.1	DNA repair protein RadC	-
FDZ05_RS24170	5085903..5086346	-	444	WP_047724684.1	antirestriction protein	-
FDZ05_RS24175	5086426..5086674	-	249	WP_047725179.1	DUF905 domain-containing protein	-
FDZ05_RS24180	5086680..5087504	-	825	WP_047724685.1	DUF945 domain-containing protein	-
FDZ05_RS24185	5087748..5088569	-	822	WP_047724687.1	hypothetical protein	-
FDZ05_RS24190	5089207..5089839	+	633	WP_047724689.1	inovirus Gp2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (3-111)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14425.51 Da
• Isoelectric Point: 8.0784

>T125090 WP_047724668.1 NZ_CP040183:c5084736-5084347 [Raoultella planticola]
MQTKLSPLMRAASSRPSPVDVWQTLLTCLLEHHYGLTLNDTPFSDEQVIQQHIEAGISLADALNFIVEKYELVRTDRPGF
SIMEQSPFITAIDILRARKATGLMNRGTYKEVTAITRGQHPQASTSGKR

Nucleotide

• Length: 390 bp

>T125090 NZ_CP040183:c5084736-5084347 [Raoultella planticola]
ATGCAAACCAAATTATCCCCCCTCATGCGGGCGGCATCGTCACGCCCGTCTCCCGTTGATGTCTGGCAGACCCTGCTGAC
CTGCCTGCTGGAACACCACTATGGCCTCACGCTTAATGACACGCCGTTCAGTGATGAACAGGTGATTCAGCAACATATCG
AGGCGGGTATCTCTCTGGCCGATGCCCTGAATTTCATTGTTGAAAAGTATGAACTGGTTCGCACTGACCGGCCAGGCTTC
AGCATTATGGAGCAGTCTCCGTTTATTACGGCCATTGATATCCTCCGGGCCAGAAAGGCTACGGGGCTGATGAACCGTGG
CACGTATAAAGAGGTGACGGCTATTACCAGAGGACAACATCCGCAGGCCAGCACTTCAGGCAAGCGATGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12133.85 Da
• Isoelectric Point: 6.9459

>AT125090 WP_171972752.1 NZ_CP040183:c5085119-5084793 [Raoultella planticola]
ISEPWWGLRRSVSPCFGARLVQEGNRLHYLADRANFNGQFCDADLRHLDQAFPVLMKQLELMLTSGELNPRHQHCVTLYA
KGLTCEADTLGSHGYVYIAIYPTPVATA

Nucleotide

• Length: 327 bp

>AT125090 NZ_CP040183:c5085119-5084793 [Raoultella planticola]
ATCAGCGAACCCTGGTGGGGGCTCAGACGCAGTGTCTCCCCGTGTTTTGGTGCCCGTCTGGTCCAGGAGGGAAACCGCCT
GCATTACCTGGCTGACCGCGCGAATTTTAACGGACAGTTCTGCGATGCGGATTTGCGCCATCTTGACCAGGCCTTCCCGG
TACTGATGAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTGAATCCCCGTCATCAGCACTGCGTCACACTGTATGCA
AAAGGTCTGACCTGCGAGGCCGATACGCTCGGTTCGCACGGTTACGTTTATATCGCGATTTATCCCACTCCTGTAGCCAC
GGCATAA