Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4436551..4437170 Replicon chromosome
Accession NZ_CP040183
Organism Raoultella planticola strain Rp_CZ180511

Toxin (Protein)


Gene name Hha Uniprot ID A0A514EV16
Locus tag FDZ05_RS21080 Protein ID WP_004858783.1
Coordinates 4436952..4437170 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A514EV88
Locus tag FDZ05_RS21075 Protein ID WP_004858785.1
Coordinates 4436551..4436925 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDZ05_RS21065 4431662..4432855 + 1194 WP_032689203.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FDZ05_RS21070 4432878..4436024 + 3147 WP_032689204.1 multidrug efflux RND transporter permease subunit -
FDZ05_RS21075 4436551..4436925 + 375 WP_004858785.1 Hha toxicity modulator TomB Antitoxin
FDZ05_RS21080 4436952..4437170 + 219 WP_004858783.1 hemolysin expression modulator Hha Toxin
FDZ05_RS21085 4437322..4437888 + 567 WP_032689205.1 maltose O-acetyltransferase -
FDZ05_RS21090 4437988..4438458 + 471 WP_004858780.1 YlaC family protein -
FDZ05_RS21095 4438433..4439884 - 1452 WP_180888691.1 PLP-dependent aminotransferase family protein -
FDZ05_RS21100 4439986..4440696 + 711 WP_032689207.1 GNAT family N-acetyltransferase -
FDZ05_RS21105 4440693..4440833 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
FDZ05_RS21110 4440836..4441096 - 261 WP_032689208.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8570.90 Da        Isoelectric Point: 7.9907

>T125089 WP_004858783.1 NZ_CP040183:4436952-4437170 [Raoultella planticola]
MSGEPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T125089 NZ_CP040183:4436952-4437170 [Raoultella planticola]
ATGTCTGGTGAACCATTAACCAAAACAGACTATTTGATGCGCTTACGTCGCTGTCAGACAATTGATACGCTGGAACGCGT
AATTGAAAAAAACAAATATGAACTTTCAGATAACGAACTGGCTGTATTTTACTCAGCGGCCGATCACCGTCTTGCTGAAT
TGACCATGAATAAACTCTACGACAAAATCCCGACATCGGTGTGGAAGTTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14411.19 Da        Isoelectric Point: 4.8989

>AT125089 WP_004858785.1 NZ_CP040183:4436551-4436925 [Raoultella planticola]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYAEDNKLIAQLDEYL
DDTFMLFSSYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT125089 NZ_CP040183:4436551-4436925 [Raoultella planticola]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCGCAGCTTCGATTTCTTTGCGAAACCCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGTAACCACGGGTGGGTGAATGACCCGACGTCGGCTATCAATCTTCAACTTAATGAATTGATCGAAC
ACATAGCCACGTTCGCGCTTAATTATAAAATTAAGTATGCTGAGGATAATAAACTGATCGCTCAGCTGGACGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGCATTAACACGGCCGATCTACAGAAATGGCGCAAATCGGGAAATCGGTT
ATTCCGATGTTTTGTCAACGCCAGCCGGGAAAATCCGGCAAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A514EV16

Antitoxin

Source ID Structure
AlphaFold DB A0A514EV88

References