Detailed information of TA system TA125077

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 783903..784656
• Replicon: chromosome
• Accession: NZ_CP040183
• Organism: Raoultella planticola strain Rp_CZ180511

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: R8WN26
• Locus tag: FDZ05_RS03820
• Protein ID: WP_016154457.1
• Coordinates: 783903..784280 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: FDZ05_RS03825
• Protein ID: WP_162838704.1
• Coordinates: 784330..784656 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDZ05_RS03785	780157..780735	+	579	WP_180888861.1	TetR/AcrR family transcriptional regulator	-
FDZ05_RS03790	780736..781193	-	458	Protein_744	iron-containing redox enzyme family protein	-
FDZ05_RS03795	781177..781659	+	483	WP_180888862.1	alpha-glucosidase C-terminal domain-containing protein	-
FDZ05_RS03800	781993..782244	-	252	WP_143520598.1	hypothetical protein	-
FDZ05_RS03805	782256..783101	-	846	Protein_747	DUF4942 domain-containing protein	-
FDZ05_RS03810	783182..783385	-	204	WP_009652505.1	DUF957 domain-containing protein	-
FDZ05_RS03815	783415..783906	-	492	WP_009652438.1	hypothetical protein	-
FDZ05_RS03820	783903..784280	-	378	WP_016154457.1	TA system toxin CbtA family protein	Toxin
FDZ05_RS03825	784330..784656	-	327	WP_162838704.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FDZ05_RS03830	784713..784934	-	222	WP_009652392.1	DUF987 domain-containing protein	-
FDZ05_RS03835	784948..785430	-	483	WP_016154455.1	DNA repair protein RadC	-
FDZ05_RS03840	785442..785660	-	219	WP_009652503.1	hypothetical protein	-
FDZ05_RS03845	785671..786132	-	462	WP_045890390.1	antirestriction protein	-
FDZ05_RS03850	786161..786415	-	255	WP_009652519.1	hypothetical protein	-
FDZ05_RS03855	786415..787233	-	819	WP_009652424.1	DUF945 domain-containing protein	-
FDZ05_RS03860	787337..787570	-	234	WP_009652474.1	DUF905 domain-containing protein	-
FDZ05_RS03865	787626..787847	-	222	WP_009652443.1	hypothetical protein	-
FDZ05_RS03870	787930..788442	-	513	WP_009652395.1	DUF4234 domain-containing protein	-
FDZ05_RS03875	788491..788961	-	471	WP_009652431.1	hypothetical protein	-
FDZ05_RS03880	789008..789319	-	312	WP_009652410.1	hypothetical protein	-
FDZ05_RS03885	789332..789598	-	267	WP_009652486.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14168.19 Da
• Isoelectric Point: 9.5224

>T125077 WP_016154457.1 NZ_CP040183:c784280-783903 [Raoultella planticola]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP

Nucleotide

• Length: 378 bp

>T125077 NZ_CP040183:c784280-783903 [Raoultella planticola]
ATGCAAACACAACCTGTTCCTCCGAAACGGGAGGTTTCGCCACGCCCGTCACCCGTGGCGATCTGGCAGCGCCTCCTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGCTCAACGACACGCCATTTGGCAAAGATGGTGTGATCCAAGAGCATATCG
ATGCCGGTATCTCACTGTGCGACGCGGTGAATTTCATCGTGGAGAAATACGACCTGGTACGCACTGATCGTCGCGGTTTT
AACGCGGAAACTCAGTCGCCGCTTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGCTGATGACCCGTCA
TAGCTACAGGGCCGTTACCGACATCACCACCGGCAAATACCGTGAGGTGCAACCATGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12079.85 Da
• Isoelectric Point: 6.6283

>AT125077 WP_162838704.1 NZ_CP040183:c784656-784330 [Raoultella planticola]
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE

Nucleotide

• Length: 327 bp

>AT125077 NZ_CP040183:c784656-784330 [Raoultella planticola]
ATCGCCGCCCCTTGGTGGGGGCTTAAACGCGATATCACCCCCTGTTTTGGCGCACGTCTGGTGCAGGAGGGCAACCGGCT
GCATTACCTGAACGACCGCGCCAGCATCACCGGCACCTTCAGCGACGCGGATTTACGCCATCTCGACCAGGCATTCCCGC
TACTGCTGAAGCAACTGGAGCTGATGCTGCTTTCCGGTGAGCTGAATCCCCGTCATCAGCACTGCGTCACGCTGTATGCA
AAAGGGCTGATATGCGAGGCCGACAGCCTCGGCTCGCACGGGTACGTCTATCTCGCAATTTACCCGACACCTGCAACAAC
AGAATAA

Structures

Toxin

• AlphaFold DB: R8WN26