Detailed information of TA system TA125076

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE(toxin)
• Location: 5225642..5226164
• Replicon: chromosome
• Accession: NZ_CP040182
• Organism: Serratia fonticola strain MS5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0U4JRE1
• Locus tag: FD644_RS24065
• Protein ID: WP_021806920.1
• Coordinates: 5225883..5226164 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8I0CUG0
• Locus tag: FD644_RS24060
• Protein ID: WP_071682601.1
• Coordinates: 5225642..5225893 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD644_RS24050	5223260..5224717	-	1458	WP_071682599.1	EmmdR/YeeO family multidrug/toxin efflux MATE transporter	-
FD644_RS24055	5224924..5225577	+	654	WP_071682600.1	Qnr family pentapeptide repeat protein	-
FD644_RS24060	5225642..5225893	+	252	WP_071682601.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FD644_RS24065	5225883..5226164	+	282	WP_021806920.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FD644_RS24070	5226333..5226968	+	636	WP_071682602.1	glutathione transferase	-
FD644_RS24075	5227079..5228533	-	1455	WP_071682603.1	NAD-dependent succinate-semialdehyde dehydrogenase	-
FD644_RS24080	5228546..5229811	-	1266	WP_071682604.1	4-aminobutyrate--2-oxoglutarate transaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10991.89 Da
• Isoelectric Point: 10.6704

>T125076 WP_021806920.1 NZ_CP040182:5225883-5226164 [Serratia fonticola]
MTYKLKFEKRALKEWEKLGYPVREQLKKKLAERLENPHVPASRLSGRPNRYKIKLRSSGYRLVYEVRDNEIVLLVIAVGK
RAGEEVYFAADKR

Nucleotide

• Length: 282 bp

>T125076 NZ_CP040182:5225883-5226164 [Serratia fonticola]
ATGACTTATAAGCTCAAATTTGAAAAGCGCGCACTGAAGGAATGGGAAAAGCTGGGCTATCCCGTTCGGGAACAACTGAA
AAAGAAGCTGGCCGAGCGTTTAGAAAACCCGCATGTGCCCGCATCCCGCCTAAGTGGCCGCCCGAACCGTTACAAAATCA
AACTGCGCTCATCAGGCTATCGGTTGGTTTATGAAGTACGTGATAATGAAATTGTTCTATTGGTGATCGCCGTTGGAAAA
CGGGCTGGGGAGGAAGTCTATTTTGCTGCCGATAAGCGATAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9242.38 Da
• Isoelectric Point: 3.8427

>AT125076 WP_071682601.1 NZ_CP040182:5225642-5225893 [Serratia fonticola]
MAFQILTTIAASITDLKKNPMGTVADGEGEAVAILNRNEPAFYCVPPELYAYYRELAEDAELNRIADERMEDAEFVSVNL
NDL

Nucleotide

• Length: 252 bp

>AT125076 NZ_CP040182:5225642-5225893 [Serratia fonticola]
ATGGCCTTTCAAATTTTAACCACTATCGCTGCCAGCATCACCGACCTGAAAAAGAATCCTATGGGAACCGTTGCAGACGG
AGAAGGTGAAGCGGTTGCCATCCTGAATCGTAACGAACCGGCTTTCTACTGCGTGCCCCCTGAGCTGTATGCATACTATC
GGGAGCTTGCCGAAGATGCAGAATTAAACCGTATTGCAGATGAACGCATGGAAGATGCGGAGTTTGTGAGCGTAAATCTT
AATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A0U4JRE1