Detailed information of TA system TA125075

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4753191..4753860
• Replicon: chromosome
• Accession: NZ_CP040182
• Organism: Serratia fonticola strain MS5

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A8H9YD80
• Locus tag: FD644_RS21870
• Protein ID: WP_071681918.1
• Coordinates: 4753191..4753613 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: U2M6Q5
• Locus tag: FD644_RS21875
• Protein ID: WP_021179805.1
• Coordinates: 4753594..4753860 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD644_RS21850	4749035..4749553	+	519	WP_071681912.1	flavodoxin FldB	-
FD644_RS21855	4749589..4750977	-	1389	WP_071681914.1	cell envelope integrity protein CreD	-
FD644_RS21860	4751081..4752499	-	1419	WP_071681916.1	two-component system sensor histidine kinase CreC	-
FD644_RS21865	4752496..4753191	-	696	WP_021806195.1	two-component system response regulator CreB	-
FD644_RS21870	4753191..4753613	-	423	WP_071681918.1	protein YgfX	Toxin
FD644_RS21875	4753594..4753860	-	267	WP_021179805.1	FAD assembly factor SdhE	Antitoxin
FD644_RS21880	4754161..4755153	+	993	WP_037375809.1	tRNA-modifying protein YgfZ	-
FD644_RS21885	4755193..4755690	-	498	WP_071681920.1	DUF2165 domain-containing protein	-
FD644_RS21890	4755922..4756596	-	675	WP_071681922.1	hemolysin III family protein	-
FD644_RS21895	4756834..4757442	+	609	WP_071681924.1	HD domain-containing protein	-
FD644_RS21900	4757476..4758222	-	747	WP_071681926.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-78)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16523.49 Da
• Isoelectric Point: 10.6373

>T125075 WP_071681918.1 NZ_CP040182:c4753613-4753191 [Serratia fonticola]
VALWRCDVRVSWRTQLVSLLTHGLLILLILIAPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLAERRIEWHGR
EWLMVNKPWMPGFGILLSLQQIDGKKRHRLWLASDSMSKADWRQLRQRLLFEQSATDEDV

Nucleotide

• Length: 423 bp

>T125075 NZ_CP040182:c4753613-4753191 [Serratia fonticola]
GTGGCCCTGTGGCGATGTGATGTCCGCGTTTCCTGGCGTACCCAGTTAGTCTCGTTGCTGACTCACGGCCTGCTGATTTT
GCTGATCCTGATCGCCCCGTGGCCGGAAGGCTATGGCCCGATCTGGTTGGTGCTGTTGACGTTGGTGGTGTTTGAGTGCA
TTCGCAGCCAAAAGCGCATTGCATCCAGGCAGGGAGAACTGCGGTTGCTGGCTGAACGCCGGATTGAGTGGCATGGCCGA
GAATGGCTGATGGTGAACAAGCCCTGGATGCCTGGGTTCGGTATTTTGCTGTCGCTTCAGCAGATCGACGGCAAGAAACG
CCATCGGCTGTGGTTGGCTTCGGATTCCATGAGCAAAGCGGATTGGCGCCAACTGCGTCAACGGTTGTTGTTTGAACAAT
CCGCTACTGATGAGGACGTATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10363.93 Da
• Isoelectric Point: 5.5847

>AT125075 WP_021179805.1 NZ_CP040182:c4753860-4753594 [Serratia fonticola]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDADKAVFIRLLECDDPDLFNWLMNHGAPQDQDLQRMVSLIQMRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT125075 NZ_CP040182:c4753860-4753594 [Serratia fonticola]
ATGGATATTAATAATAAAGCACGTATTCACTGGGCCTGCCGCCGCGGCATGCGCGAGTTGGATATCTCGATTATGCCGTT
TTTCGAACATGAATACGATACGCTGAGTGATGCAGACAAGGCCGTATTCATCCGCTTGCTCGAATGTGACGACCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCTCCGCAGGATCAAGATCTGCAGAGAATGGTGTCCCTGATCCAAATGCGAAAT
AAAGCCCGTGGCCCTGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: U2M6Q5