125074

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4490357..4491020 Replicon chromosome
Accession NZ_CP040182
Organism Serratia fonticola strain MS5

Toxin (Protein)


Gene name tad Uniprot ID A0A8H9YC74
Locus tag FD644_RS20665 Protein ID WP_071683941.1
Coordinates 4490357..4490701 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag FD644_RS20670 Protein ID WP_024484273.1
Coordinates 4490703..4491020 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD644_RS20645 4486544..4487050 - 507 WP_024484269.1 tRNA adenosine(34) deaminase TadA -
FD644_RS20650 4487379..4488530 + 1152 WP_059201549.1 L-threonine dehydrogenase -
FD644_RS20655 4488569..4489216 - 648 WP_021807693.1 phosphatidylglycerophosphatase C -
FD644_RS20660 4489447..4490256 + 810 WP_071683940.1 MurR/RpiR family transcriptional regulator -
FD644_RS20665 4490357..4490701 + 345 WP_071683941.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FD644_RS20670 4490703..4491020 + 318 WP_024484273.1 helix-turn-helix domain-containing protein Antitoxin
FD644_RS20675 4491099..4491359 + 261 WP_071683942.1 YfhL family 4Fe-4S dicluster ferredoxin -
FD644_RS20680 4491553..4491933 - 381 WP_071683944.1 holo-ACP synthase -
FD644_RS20685 4491933..4492664 - 732 WP_071683945.1 pyridoxine 5'-phosphate synthase -
FD644_RS20690 4492739..4493470 - 732 WP_021178899.1 DNA repair protein RecO -
FD644_RS20695 4493479..4494387 - 909 WP_024529374.1 GTPase Era -
FD644_RS20700 4494384..4495064 - 681 WP_021178901.1 ribonuclease III -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12507.28 Da        Isoelectric Point: 9.6410

>T125074 WP_071683941.1 NZ_CP040182:4490357-4490701 [Serratia fonticola]
MKPLYWVGSSKKDLQSLPEEVQDVFGYALHLAQAGGKHSQTKPLRGFGGAGVLEVVEDFLTDTYRAVYTVKFGDAVYVLH
AFQKKSSAGIATPKPDMDKIRERLKAAENHARGA

Download         Length: 345 bp

>T125074 NZ_CP040182:4490357-4490701 [Serratia fonticola]
ATGAAGCCACTATATTGGGTTGGTAGCAGTAAGAAAGACCTCCAGTCATTACCCGAAGAGGTTCAGGATGTTTTCGGCTA
TGCTCTACACTTGGCGCAGGCAGGTGGTAAGCATTCCCAGACGAAACCCTTAAGAGGGTTTGGTGGGGCAGGAGTACTAG
AGGTAGTAGAAGACTTTCTTACTGATACTTATCGTGCAGTCTATACCGTTAAGTTTGGTGATGCCGTGTATGTTCTGCAC
GCATTCCAGAAAAAGTCTTCAGCCGGGATCGCCACACCGAAACCAGATATGGACAAAATCCGTGAACGACTGAAAGCCGC
AGAAAATCATGCCAGAGGGGCATAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11403.22 Da        Isoelectric Point: 10.2057

>AT125074 WP_024484273.1 NZ_CP040182:4490703-4491020 [Serratia fonticola]
MSQDIEVSSGNVYADIGSDGAEEMQVKAQLASTIGDIIKSRRLTQEQAAKLLGMTQPKLSNLLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSLKVVFA

Download         Length: 318 bp

>AT125074 NZ_CP040182:4490703-4491020 [Serratia fonticola]
ATGAGCCAAGATATCGAAGTCAGCAGCGGCAACGTTTATGCCGATATTGGCAGCGACGGCGCTGAAGAAATGCAGGTTAA
AGCCCAACTTGCCAGCACAATTGGCGACATCATCAAAAGTCGCCGTCTGACACAAGAGCAGGCCGCAAAGCTCCTGGGGA
TGACACAGCCCAAGCTGTCTAATCTGTTGCGCGGCCAGTTCCGGGGCATCAGCGAAGCCAAAATGCTAGAATGCCTGACC
CGCTTAGGGCGTGATGTACAAATTGTGGTAGGCAAGCCACGCCGGACACCCGGCAGTCTTAAAGTGGTGTTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References