Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4367733..4368389 Replicon chromosome
Accession NZ_CP040182
Organism Serratia fonticola strain MS5

Toxin (Protein)


Gene name vapC Uniprot ID A0A8H9YAX7
Locus tag FD644_RS20120 Protein ID WP_071683877.1
Coordinates 4367733..4368122 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8H9YB07
Locus tag FD644_RS20125 Protein ID WP_071683878.1
Coordinates 4368126..4368389 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD644_RS20105 4364188..4365633 + 1446 WP_071683875.1 MFS transporter -
FD644_RS20110 4365630..4367000 + 1371 WP_071683876.1 two-component system sensor histidine kinase BaeS -
FD644_RS20115 4367013..4367729 + 717 WP_059201493.1 two-component system response regulator BaeR -
FD644_RS20120 4367733..4368122 - 390 WP_071683877.1 type II toxin-antitoxin system VapC family toxin Toxin
FD644_RS20125 4368126..4368389 - 264 WP_071683878.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FD644_RS20130 4368736..4369074 + 339 WP_071683879.1 YegP family protein -
FD644_RS20135 4369255..4370607 + 1353 WP_059201494.1 tRNA 5-hydroxyuridine modification protein YegQ -
FD644_RS20140 4371143..4372042 + 900 WP_071683880.1 lipid kinase YegS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14246.52 Da        Isoelectric Point: 7.8799

>T125073 WP_071683877.1 NZ_CP040182:c4368122-4367733 [Serratia fonticola]
MYMFDTNTVSQLFRQHPRLLAAMGRVPPSSVCISSISQAELLYGVAKRQNKALKQTVMMFLDAVTVYSWDSAAAHCYGVM
RASMEKQGRPMGALDQLIAAHAVSRGATIVTSDRAFTMVAELEVEDWTL

Download         Length: 390 bp

>T125073 NZ_CP040182:c4368122-4367733 [Serratia fonticola]
ATGTATATGTTCGACACTAACACGGTGAGCCAGCTTTTTCGTCAGCATCCTCGGCTGCTTGCGGCTATGGGCCGGGTACC
GCCATCGTCGGTGTGTATTTCCAGCATATCCCAGGCGGAACTGCTTTATGGCGTCGCCAAGCGGCAGAACAAGGCGCTAA
AACAGACGGTGATGATGTTCCTGGACGCCGTCACCGTTTACTCCTGGGACTCTGCGGCGGCGCATTGCTATGGTGTCATG
CGCGCAAGTATGGAAAAACAAGGCAGACCGATGGGGGCGTTGGATCAGCTTATTGCCGCACATGCGGTAAGCCGTGGCGC
AACCATAGTGACCAGCGATCGGGCTTTCACTATGGTCGCGGAGCTTGAGGTGGAAGACTGGACGCTGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10171.56 Da        Isoelectric Point: 4.8232

>AT125073 WP_071683878.1 NZ_CP040182:c4368389-4368126 [Serratia fonticola]
MERVAKLFKNGRNQAVRLPVEFEFDVDQVYIRRDEQGNVILSKHPMKLDSWQPLLTMLQNVAVPADFLTADDRQQGIAER
DPFKEEQ

Download         Length: 264 bp

>AT125073 NZ_CP040182:c4368389-4368126 [Serratia fonticola]
ATGGAAAGAGTCGCCAAGCTTTTTAAAAACGGTAGAAATCAGGCGGTGAGATTGCCAGTGGAATTCGAATTCGATGTCGA
TCAGGTTTATATTCGCCGGGATGAACAGGGTAACGTTATCTTGTCGAAGCACCCAATGAAATTGGACTCCTGGCAACCGC
TACTGACCATGCTGCAAAACGTGGCGGTTCCTGCTGACTTCCTGACTGCTGACGATCGCCAGCAAGGGATAGCAGAACGG
GATCCGTTCAAGGAGGAACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References