Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 3988689..3989478 Replicon chromosome
Accession NZ_CP040182
Organism Serratia fonticola strain MS5

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8I0CS63
Locus tag FD644_RS18420 Protein ID WP_071684019.1
Coordinates 3988689..3989024 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8I0CTB2
Locus tag FD644_RS18425 Protein ID WP_071684020.1
Coordinates 3989110..3989478 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD644_RS18375 3983911..3984120 + 210 WP_071684010.1 hypothetical protein -
FD644_RS18380 3984197..3984658 + 462 WP_071684011.1 hypothetical protein -
FD644_RS18385 3984989..3985810 + 822 WP_071684012.1 DUF945 domain-containing protein -
FD644_RS18395 3986418..3986870 + 453 WP_071684014.1 antirestriction protein -
FD644_RS18400 3986881..3987366 + 486 WP_071684015.1 DNA repair protein RadC -
FD644_RS18405 3987443..3987820 + 378 WP_071684016.1 hypothetical protein -
FD644_RS18410 3987820..3988134 + 315 WP_071684017.1 hypothetical protein -
FD644_RS18415 3988194..3988676 + 483 WP_071684018.1 hypothetical protein -
FD644_RS18420 3988689..3989024 + 336 WP_071684019.1 TA system toxin CbtA family protein Toxin
FD644_RS18425 3989110..3989478 + 369 WP_071684020.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FD644_RS18430 3989557..3990414 + 858 WP_071684021.1 DUF4942 domain-containing protein -
FD644_RS18440 3990896..3991225 - 330 WP_021805952.1 osmotically-inducible lipoprotein OsmE -
FD644_RS18445 3991305..3991721 - 417 WP_071684022.1 VOC family protein -
FD644_RS18450 3991876..3992991 - 1116 WP_021178487.1 porin OmpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(17-103)

Antitoxin

Antitoxin CbeA

(18-116)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12505.31 Da        Isoelectric Point: 5.6894

>T125072 WP_071684019.1 NZ_CP040182:3988689-3989024 [Serratia fonticola]
MKTLDKIPCIAPNANQARTEYQQLLTWLLAHCYGLELNDTPYHDDQAIAQQIEQGVTVRETINELVEKFDLVRIDRPGFS
LMAQDPTLNGGDMLRARSALGLRSPAIRRLA

Download         Length: 336 bp

>T125072 NZ_CP040182:3988689-3989024 [Serratia fonticola]
ATGAAGACTCTCGACAAAATACCCTGCATCGCGCCCAACGCCAACCAAGCACGAACTGAATACCAGCAACTGCTCACCTG
GTTGCTGGCTCACTGTTATGGCTTGGAGCTTAACGATACGCCCTATCACGACGACCAAGCTATTGCTCAACAAATTGAGC
AGGGCGTCACGGTACGGGAAACCATCAATGAACTGGTGGAGAAATTTGATCTGGTACGTATTGATCGCCCCGGTTTCAGC
CTGATGGCACAAGACCCCACCCTGAACGGTGGCGATATGTTACGCGCCCGCAGTGCGCTGGGCTTGCGCAGTCCCGCCAT
TCGACGCCTGGCCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13128.78 Da        Isoelectric Point: 4.9764

>AT125072 WP_071684020.1 NZ_CP040182:3989110-3989478 [Serratia fonticola]
MKETQSNAASNDSTPSPVWGLQSAITPRLGARLVQQGNYLHFLADRAGFVGTFSPDALKTLDAALPALIEQLEACLLSGE
LDPRRQHCVTVQHAGFSCEADSLGSFGYVYFAVYQTTPPNLV

Download         Length: 369 bp

>AT125072 NZ_CP040182:3989110-3989478 [Serratia fonticola]
ATGAAGGAAACCCAATCCAATGCCGCCAGCAACGACAGCACTCCGTCGCCTGTCTGGGGCCTGCAATCTGCTATCACACC
ACGTTTGGGGGCCAGATTGGTTCAGCAGGGCAACTACCTGCACTTTCTGGCTGACCGCGCCGGTTTTGTCGGTACGTTCT
CCCCTGATGCGCTTAAAACTCTGGATGCCGCTTTACCTGCGCTGATTGAACAACTGGAAGCCTGTCTGCTGTCTGGTGAA
CTCGATCCACGCCGTCAGCACTGCGTCACCGTCCAGCACGCCGGTTTTAGCTGTGAAGCGGATTCGCTAGGTAGTTTTGG
GTATGTTTATTTCGCTGTTTATCAGACAACACCGCCCAACCTGGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References