Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3601581..3602210 Replicon chromosome
Accession NZ_CP040182
Organism Serratia fonticola strain MS5

Toxin (Protein)


Gene name hicA Uniprot ID A0A8H9YFF8
Locus tag FD644_RS16495 Protein ID WP_071680879.1
Coordinates 3601581..3601769 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A8H9YGZ4
Locus tag FD644_RS16500 Protein ID WP_071680880.1
Coordinates 3601797..3602210 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD644_RS16485 3599608..3600237 - 630 WP_071680877.1 TetR/AcrR family transcriptional regulator -
FD644_RS16490 3600446..3601381 + 936 WP_071680878.1 nitronate monooxygenase -
FD644_RS16495 3601581..3601769 + 189 WP_071680879.1 type II toxin-antitoxin system HicA family toxin Toxin
FD644_RS16500 3601797..3602210 + 414 WP_071680880.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FD644_RS16505 3602243..3602995 - 753 WP_021805696.1 L-cystine ABC transporter ATP-binding protein YecC -
FD644_RS16510 3602999..3603661 - 663 WP_021180972.1 cystine ABC transporter permease -
FD644_RS16515 3603661..3604461 - 801 WP_021180971.1 cystine ABC transporter substrate-binding protein -
FD644_RS16520 3604580..3605566 - 987 WP_071680881.1 D-cysteine desulfhydrase -
FD644_RS16525 3605693..3606202 - 510 WP_065684264.1 flagella biosynthesis regulatory protein FliZ -
FD644_RS16530 3606263..3606985 - 723 WP_021180968.1 RNA polymerase sigma factor FliA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7008.14 Da        Isoelectric Point: 10.4931

>T125071 WP_071680879.1 NZ_CP040182:3601581-3601769 [Serratia fonticola]
VNSSELIKRLESHGWVLQRIKGCHHQFKHPNSSLVITVPHPNKDVKLGTLRQIMKDAGLLDS

Download         Length: 189 bp

>T125071 NZ_CP040182:3601581-3601769 [Serratia fonticola]
GTGAACAGTTCAGAACTGATTAAACGACTCGAAAGCCATGGCTGGGTTTTACAACGGATCAAAGGCTGCCACCATCAATT
CAAACACCCCAACTCATCGTTGGTGATCACCGTGCCTCATCCCAATAAGGATGTGAAATTGGGAACGCTGCGGCAAATCA
TGAAGGATGCAGGGTTGCTTGATTCCTAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15002.77 Da        Isoelectric Point: 5.4970

>AT125071 WP_071680880.1 NZ_CP040182:3601797-3602210 [Serratia fonticola]
MFYPAYIHAEPDGSASGFFPDVPGCYFAGDSLDQTFQDAKSALDAHFELLSKDNQAIPRPQAVSFHLAQGNDALNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKAG

Download         Length: 414 bp

>AT125071 NZ_CP040182:3601797-3602210 [Serratia fonticola]
ATGTTTTATCCTGCTTATATACATGCCGAGCCGGATGGCAGCGCCAGCGGTTTTTTTCCCGATGTACCCGGCTGCTACTT
TGCCGGAGACAGTCTCGATCAAACCTTCCAGGATGCCAAAAGCGCTCTGGATGCCCACTTTGAATTATTGAGTAAAGACA
ATCAGGCCATTCCACGCCCGCAGGCGGTGTCCTTCCATCTGGCTCAGGGCAACGACGCCCTCAACGGCGGCCAGTGGTTG
CTGGTGGATATCAATATGGACAAGTTCGATGGCCGGGCTGAACGTATCAATATCACGTTGCCCCACCGGCTGCTCAACCG
TATTGATTCGCTGGTGCAACAGCATCCGGGCTATGGCAGCCGCAGCGCATTTCTCGCCGCCGCAGCGCGTAATGAATTGT
TAAAAGCAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References