Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1592806..1593428 Replicon chromosome
Accession NZ_CP040182
Organism Serratia fonticola strain MS5

Toxin (Protein)


Gene name Hha Uniprot ID U2M374
Locus tag FD644_RS07180 Protein ID WP_021180142.1
Coordinates 1592806..1593009 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID U2NAN4
Locus tag FD644_RS07185 Protein ID WP_021180141.1
Coordinates 1593060..1593428 (-) Length 123 a.a.

Genomic Context

FD644_RS07155FD644_RS07175FD644_RS07195FD644_RS07200FD644_RS07205FD644_RS07160FD644_RS07170FD644_RS07180FD644_RS07185FD644_RS07190FD644_RS07210FD644_RS07215
Location: 1588615..1589103 (489 bp)
Type: Others
Protein ID: WP_071683006.1
Location: 1591798..1592724 (927 bp)
Type: Others
Protein ID: WP_024484393.1
Location: 1594319..1595011 (693 bp)
Type: Others
Protein ID: WP_071683065.1
Location: 1595011..1595868 (858 bp)
Type: Others
Protein ID: WP_059200028.1
Location: 1595894..1596772 (879 bp)
Type: Others
Protein ID: WP_071683004.1
Location: 1589158..1589472 (315 bp)
Type: Others
Protein ID: WP_021180150.1
Location: 1589874..1591661 (1788 bp)
Type: Others
Protein ID: WP_071683005.1
Location: 1592806..1593009 (204 bp)
Type: Toxin
Protein ID: WP_021180142.1
Location: 1593060..1593428 (369 bp)
Type: Antitoxin
Protein ID: WP_021180141.1
Location: 1593586..1593939 (354 bp)
Type: Others
Protein ID: WP_071683066.1
Location: 1596880..1597020 (141 bp)
Type: Others
Protein ID: WP_021805462.1
Location: 1597033..1597290 (258 bp)
Type: Others
Protein ID: WP_071683003.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FD644_RS071551588615..1589103+489WP_071683006.1YbaY family lipoprotein-
FD644_RS071601589158..1589472-315WP_021180150.1MGMT family protein-
FD644_RS071701589874..1591661-1788WP_071683005.1adenine deaminase-
FD644_RS071751591798..1592724+927WP_024484393.1LysR family transcriptional regulator-
FD644_RS071801592806..1593009-204WP_021180142.1hemolysin expression modulator HhaToxin
FD644_RS071851593060..1593428-369WP_021180141.1Hha toxicity modulator TomBAntitoxin
FD644_RS071901593586..1593939-354WP_071683066.1hypothetical protein-
FD644_RS071951594319..1595011+693WP_071683065.1ABC transporter ATP-binding protein-
FD644_RS072001595011..1595868+858WP_059200028.1metal ABC transporter permease-
FD644_RS072051595894..1596772+879WP_071683004.1zinc ABC transporter substrate-binding protein-
FD644_RS072101596880..1597020-141WP_021805462.1type B 50S ribosomal protein L36-
FD644_RS072151597033..1597290-258WP_071683003.1type B 50S ribosomal protein L31-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8099.48 Da        Isoelectric Point: 6.9770

>T125061 WP_021180142.1 NZ_CP040182:c1593009-1592806 [Serratia fonticola]
MTKIDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T125061 NZ_CP040182:c1593009-1592806 [Serratia fonticola]
ATGACAAAAATTGACTATCTGATGCGTTTGCGTAAATGCACCACGATTGAAACCCTTGAGCGAGTGATCGAGAAAAATAA
GTACGAACTCTCTGACGATGAGCTAGAGCTGTTCTACTCTGCCGCCGATCACCGCCTGGCCGAACTGACCATGAACAAGC
TGTACGATAAAATTCCGGTCGCCGTTTGGAAATTTGTAAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14097.78 Da        Isoelectric Point: 4.5140

>AT125061 WP_021180141.1 NZ_CP040182:c1593428-1593060 [Serratia fonticola]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSFKIKYMDEGDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARTFRLFSGEGVCTTMKT

Download         Length: 369 bp

>AT125061 NZ_CP040182:c1593428-1593060 [Serratia fonticola]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAACTCAAATTCTTATGTGAAAATTTGTACGACGAAGGCATCGC
CACCCTGGGTGACAGCCACCACGGCTGGGTTAACGATCCAACGTCCGCCGTCAATCTGCAGCTTAATGAGCTGATCGAAC
ATATTGCTTCGTTTGTAATGAGTTTTAAAATTAAATACATGGACGAAGGTGATTTATCGGAACTGGTCGAAGAGTACCTC
GACGATACCTACACGCTGTTTAGCAGCTATGGTATTAATGACTCCGATTTGCGTCGCTGGCAAAAAACCAAGGCACGCAC
ATTCAGATTGTTCTCAGGAGAGGGCGTCTGTACCACGATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBU2M374

Antitoxin

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Source
ID
Structure
AlphaFold DBU2NAN4

References