Detailed information of TA system TA125061

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1592806..1593428
• Replicon: chromosome
• Accession: NZ_CP040182
• Organism: Serratia fonticola strain MS5

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: U2M374
• Locus tag: FD644_RS07180
• Protein ID: WP_021180142.1
• Coordinates: 1592806..1593009 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: U2NAN4
• Locus tag: FD644_RS07185
• Protein ID: WP_021180141.1
• Coordinates: 1593060..1593428 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD644_RS07155	1588615..1589103	+	489	WP_071683006.1	YbaY family lipoprotein	-
FD644_RS07160	1589158..1589472	-	315	WP_021180150.1	MGMT family protein	-
FD644_RS07170	1589874..1591661	-	1788	WP_071683005.1	adenine deaminase	-
FD644_RS07175	1591798..1592724	+	927	WP_024484393.1	LysR family transcriptional regulator	-
FD644_RS07180	1592806..1593009	-	204	WP_021180142.1	hemolysin expression modulator Hha	Toxin
FD644_RS07185	1593060..1593428	-	369	WP_021180141.1	Hha toxicity modulator TomB	Antitoxin
FD644_RS07190	1593586..1593939	-	354	WP_071683066.1	hypothetical protein	-
FD644_RS07195	1594319..1595011	+	693	WP_071683065.1	ABC transporter ATP-binding protein	-
FD644_RS07200	1595011..1595868	+	858	WP_059200028.1	metal ABC transporter permease	-
FD644_RS07205	1595894..1596772	+	879	WP_071683004.1	zinc ABC transporter substrate-binding protein	-
FD644_RS07210	1596880..1597020	-	141	WP_021805462.1	type B 50S ribosomal protein L36	-
FD644_RS07215	1597033..1597290	-	258	WP_071683003.1	type B 50S ribosomal protein L31	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8099.48 Da
• Isoelectric Point: 6.9770

>T125061 WP_021180142.1 NZ_CP040182:c1593009-1592806 [Serratia fonticola]
MTKIDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Nucleotide

• Length: 204 bp

>T125061 NZ_CP040182:c1593009-1592806 [Serratia fonticola]
ATGACAAAAATTGACTATCTGATGCGTTTGCGTAAATGCACCACGATTGAAACCCTTGAGCGAGTGATCGAGAAAAATAA
GTACGAACTCTCTGACGATGAGCTAGAGCTGTTCTACTCTGCCGCCGATCACCGCCTGGCCGAACTGACCATGAACAAGC
TGTACGATAAAATTCCGGTCGCCGTTTGGAAATTTGTAAGATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14097.78 Da
• Isoelectric Point: 4.5140

>AT125061 WP_021180141.1 NZ_CP040182:c1593428-1593060 [Serratia fonticola]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSFKIKYMDEGDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARTFRLFSGEGVCTTMKT

Nucleotide

• Length: 369 bp

>AT125061 NZ_CP040182:c1593428-1593060 [Serratia fonticola]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAACTCAAATTCTTATGTGAAAATTTGTACGACGAAGGCATCGC
CACCCTGGGTGACAGCCACCACGGCTGGGTTAACGATCCAACGTCCGCCGTCAATCTGCAGCTTAATGAGCTGATCGAAC
ATATTGCTTCGTTTGTAATGAGTTTTAAAATTAAATACATGGACGAAGGTGATTTATCGGAACTGGTCGAAGAGTACCTC
GACGATACCTACACGCTGTTTAGCAGCTATGGTATTAATGACTCCGATTTGCGTCGCTGGCAAAAAACCAAGGCACGCAC
ATTCAGATTGTTCTCAGGAGAGGGCGTCTGTACCACGATGAAAACTTAG

Structures

Toxin

• AlphaFold DB: U2M374

Antitoxin

• AlphaFold DB: U2NAN4