125060

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1397686..1398242 Replicon chromosome
Accession NZ_CP040182
Organism Serratia fonticola strain MS5

Toxin (Protein)


Gene name parE Uniprot ID A0A8H9YKE3
Locus tag FD644_RS06285 Protein ID WP_071682857.1
Coordinates 1397686..1397976 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U2MX00
Locus tag FD644_RS06290 Protein ID WP_021181943.1
Coordinates 1397964..1398242 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD644_RS06265 1392772..1393722 - 951 WP_071682853.1 acetyltransferase -
FD644_RS06270 1393719..1395449 - 1731 WP_071682854.1 aerobactin synthase IucA -
FD644_RS06275 1395583..1396809 + 1227 WP_071682855.1 MFS transporter -
FD644_RS06280 1396811..1397689 + 879 WP_071682856.1 siderophore-interacting protein -
FD644_RS06285 1397686..1397976 - 291 WP_071682857.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FD644_RS06290 1397964..1398242 - 279 WP_021181943.1 CopG family ribbon-helix-helix protein Antitoxin
FD644_RS06295 1398409..1399248 + 840 WP_071682858.1 MurR/RpiR family transcriptional regulator -
FD644_RS06300 1399440..1400681 + 1242 WP_071682859.1 alanine--glyoxylate aminotransferase family protein -
FD644_RS06305 1400681..1402000 + 1320 WP_071682860.1 allantoate amidohydrolase -
FD644_RS06310 1401943..1402716 - 774 WP_071682861.1 amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10937.61 Da        Isoelectric Point: 9.3939

>T125060 WP_071682857.1 NZ_CP040182:c1397976-1397686 [Serratia fonticola]
VSQLKWSPAALADVQRLYLFLAEKDNDTAKRAISKIRRSVKILALQPQVGRPVEEMPHQYREWPIEFGSSGYVVLYHFDG
TVAVLLAVRHQLEAGY

Download         Length: 291 bp

>T125060 NZ_CP040182:c1397976-1397686 [Serratia fonticola]
GTGTCACAACTAAAATGGTCACCAGCGGCATTAGCTGATGTACAACGGCTATACCTTTTTTTAGCAGAAAAGGATAACGA
CACGGCAAAGCGCGCTATCAGCAAGATCCGCCGTAGCGTAAAAATTCTAGCTCTACAACCACAGGTAGGTCGTCCGGTGG
AGGAGATGCCTCACCAATACCGCGAATGGCCTATTGAATTTGGCAGCAGCGGCTACGTGGTACTGTATCACTTTGATGGC
ACAGTCGCCGTGCTCTTGGCGGTGCGCCATCAGCTTGAAGCGGGTTACTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10862.10 Da        Isoelectric Point: 4.7997

>AT125060 WP_021181943.1 NZ_CP040182:c1398242-1397964 [Serratia fonticola]
MATATSIKIDEELKLRVQQIALARQRTAHWIMREAIREYVEREEKREALRNDALRAWETYQADGKHLTQEEADNWLANLE
KGDDTEIPECHN

Download         Length: 279 bp

>AT125060 NZ_CP040182:c1398242-1397964 [Serratia fonticola]
ATGGCTACCGCAACGTCAATTAAAATCGATGAAGAGCTTAAGCTACGTGTGCAACAAATTGCCCTAGCACGCCAGCGTAC
AGCTCATTGGATTATGCGTGAAGCGATCCGGGAATATGTCGAACGTGAAGAAAAACGCGAAGCGCTACGCAATGATGCAT
TGCGGGCATGGGAAACCTATCAGGCTGATGGTAAACATCTAACCCAGGAAGAAGCCGATAACTGGCTGGCTAATCTGGAA
AAAGGCGATGATACGGAGATCCCGGAGTGTCACAACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U2MX00

References