Detailed information of TA system TA125060

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1397686..1398242
• Replicon: chromosome
• Accession: NZ_CP040182
• Organism: Serratia fonticola strain MS5

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8H9YKE3
• Locus tag: FD644_RS06285
• Protein ID: WP_071682857.1
• Coordinates: 1397686..1397976 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U2MX00
• Locus tag: FD644_RS06290
• Protein ID: WP_021181943.1
• Coordinates: 1397964..1398242 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD644_RS06265	1392772..1393722	-	951	WP_071682853.1	acetyltransferase	-
FD644_RS06270	1393719..1395449	-	1731	WP_071682854.1	aerobactin synthase IucA	-
FD644_RS06275	1395583..1396809	+	1227	WP_071682855.1	MFS transporter	-
FD644_RS06280	1396811..1397689	+	879	WP_071682856.1	siderophore-interacting protein	-
FD644_RS06285	1397686..1397976	-	291	WP_071682857.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FD644_RS06290	1397964..1398242	-	279	WP_021181943.1	CopG family ribbon-helix-helix protein	Antitoxin
FD644_RS06295	1398409..1399248	+	840	WP_071682858.1	MurR/RpiR family transcriptional regulator	-
FD644_RS06300	1399440..1400681	+	1242	WP_071682859.1	alanine--glyoxylate aminotransferase family protein	-
FD644_RS06305	1400681..1402000	+	1320	WP_071682860.1	allantoate amidohydrolase	-
FD644_RS06310	1401943..1402716	-	774	WP_071682861.1	amidohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10937.61 Da
• Isoelectric Point: 9.3939

>T125060 WP_071682857.1 NZ_CP040182:c1397976-1397686 [Serratia fonticola]
VSQLKWSPAALADVQRLYLFLAEKDNDTAKRAISKIRRSVKILALQPQVGRPVEEMPHQYREWPIEFGSSGYVVLYHFDG
TVAVLLAVRHQLEAGY

Nucleotide

• Length: 291 bp

>T125060 NZ_CP040182:c1397976-1397686 [Serratia fonticola]
GTGTCACAACTAAAATGGTCACCAGCGGCATTAGCTGATGTACAACGGCTATACCTTTTTTTAGCAGAAAAGGATAACGA
CACGGCAAAGCGCGCTATCAGCAAGATCCGCCGTAGCGTAAAAATTCTAGCTCTACAACCACAGGTAGGTCGTCCGGTGG
AGGAGATGCCTCACCAATACCGCGAATGGCCTATTGAATTTGGCAGCAGCGGCTACGTGGTACTGTATCACTTTGATGGC
ACAGTCGCCGTGCTCTTGGCGGTGCGCCATCAGCTTGAAGCGGGTTACTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10862.10 Da
• Isoelectric Point: 4.7997

>AT125060 WP_021181943.1 NZ_CP040182:c1398242-1397964 [Serratia fonticola]
MATATSIKIDEELKLRVQQIALARQRTAHWIMREAIREYVEREEKREALRNDALRAWETYQADGKHLTQEEADNWLANLE
KGDDTEIPECHN

Nucleotide

• Length: 279 bp

>AT125060 NZ_CP040182:c1398242-1397964 [Serratia fonticola]
ATGGCTACCGCAACGTCAATTAAAATCGATGAAGAGCTTAAGCTACGTGTGCAACAAATTGCCCTAGCACGCCAGCGTAC
AGCTCATTGGATTATGCGTGAAGCGATCCGGGAATATGTCGAACGTGAAGAAAAACGCGAAGCGCTACGCAATGATGCAT
TGCGGGCATGGGAAACCTATCAGGCTGATGGTAAACATCTAACCCAGGAAGAAGCCGATAACTGGCTGGCTAATCTGGAA
AAAGGCGATGATACGGAGATCCCGGAGTGTCACAACTAA

Structures

Antitoxin

• AlphaFold DB: U2MX00