Detailed information of TA system TA125057

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 807380..807951
• Replicon: chromosome
• Accession: NZ_CP040182
• Organism: Serratia fonticola strain MS5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FD644_RS03710
• Protein ID: WP_071681261.1
• Coordinates: 807676..807951 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U2NJB3
• Locus tag: FD644_RS03705
• Protein ID: WP_021179086.1
• Coordinates: 807380..807667 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD644_RS03675	802616..803404	-	789	WP_024483394.1	phosphonate C-P lyase system protein PhnK	-
FD644_RS03680	803404..804255	-	852	WP_071681259.1	alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ	-
FD644_RS03685	804248..805333	-	1086	WP_021807490.1	carbon-phosphorus lyase complex subunit PhnI	-
FD644_RS03690	805333..805914	-	582	WP_059199560.1	phosphonate C-P lyase system protein PhnH	-
FD644_RS03695	805918..806361	-	444	WP_071681260.1	phosphonate C-P lyase system protein PhnG	-
FD644_RS03700	806362..807090	-	729	WP_021807487.1	phosphonate metabolism transcriptional regulator PhnF	-
FD644_RS03705	807380..807667	+	288	WP_021179086.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FD644_RS03710	807676..807951	+	276	WP_071681261.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FD644_RS03715	807948..808412	-	465	WP_071681262.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
FD644_RS03720	808802..810940	-	2139	WP_071681263.1	anaerobic ribonucleoside-triphosphate reductase	-
FD644_RS03725	811252..812139	-	888	WP_071681264.1	LysR family transcriptional regulator	-
FD644_RS03730	812244..812768	+	525	WP_071681265.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-44)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10628.30 Da
• Isoelectric Point: 4.2503

>T125057 WP_071681261.1 NZ_CP040182:807676-807951 [Serratia fonticola]
MRIEWDDVALQDRERIFEFLYPLTPLAAEQVDDEIELAVESLLENPEMGRPWYGEARKLVISKASLLMIYVILDEVIKVL
AVAHQREKFPN

Nucleotide

• Length: 276 bp

>T125057 NZ_CP040182:807676-807951 [Serratia fonticola]
ATGCGCATCGAATGGGACGACGTTGCGTTGCAAGATCGGGAACGCATTTTTGAATTTCTTTATCCACTCACTCCATTGGC
CGCGGAACAAGTTGATGATGAGATTGAACTTGCCGTTGAGTCGCTGCTAGAAAACCCAGAAATGGGCAGGCCTTGGTATG
GGGAAGCTCGCAAACTGGTGATCAGTAAAGCCTCCCTATTGATGATTTATGTCATTTTGGATGAGGTGATAAAGGTTTTA
GCCGTCGCCCATCAGCGTGAAAAATTCCCCAATTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10957.35 Da
• Isoelectric Point: 8.0314

>AT125057 WP_021179086.1 NZ_CP040182:807380-807667 [Serratia fonticola]
MESRIQFRIENETKLLAQKAAEAKGTTLSEACRRLAQQMADDQRAAEEHENWLKDKVDAAFARLHEGEAVYLTQRQAEER
MSDFKAKVRAKYATK

Nucleotide

• Length: 288 bp

>AT125057 NZ_CP040182:807380-807667 [Serratia fonticola]
ATGGAAAGCCGTATCCAGTTTCGCATTGAAAATGAAACTAAACTGTTGGCACAGAAAGCTGCTGAAGCGAAAGGGACGAC
CTTAAGTGAAGCCTGTCGGCGTTTAGCGCAACAAATGGCGGACGATCAACGTGCTGCTGAAGAACACGAAAACTGGTTGA
AAGATAAGGTTGATGCAGCCTTTGCCCGTTTGCATGAAGGAGAGGCTGTTTATCTTACCCAGCGGCAAGCTGAGGAGAGA
ATGAGCGACTTTAAAGCCAAAGTCAGGGCGAAATACGCAACCAAATAA

Structures

Antitoxin

• AlphaFold DB: U2NJB3