Detailed information of TA system TA125055

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 417145..417896
• Replicon: chromosome
• Accession: NZ_CP040182
• Organism: Serratia fonticola strain MS5

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: A0A8I0CSM1
• Locus tag: FD644_RS01870
• Protein ID: WP_059199146.1
• Coordinates: 417145..417627 (-)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A3G2FKC3
• Locus tag: FD644_RS01875
• Protein ID: WP_059199145.1
• Coordinates: 417618..417896 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD644_RS01845	413180..413758	+	579	WP_071681669.1	tellurium resistance membrane protein TerD	-
FD644_RS01850	413831..414406	+	576	WP_021807716.1	TerD family protein	-
FD644_RS01855	414599..415843	+	1245	WP_071681671.1	VWA domain-containing protein	-
FD644_RS01860	416096..416311	+	216	WP_071681673.1	hypothetical protein	-
FD644_RS01865	416305..416997	-	693	WP_071681675.1	HAD-IB family hydrolase	-
FD644_RS01870	417145..417627	-	483	WP_059199146.1	GNAT family N-acetyltransferase	Toxin
FD644_RS01875	417618..417896	-	279	WP_059199145.1	DUF1778 domain-containing protein	Antitoxin
FD644_RS01880	418131..419165	+	1035	WP_071681677.1	YeeE/YedE family protein	-
FD644_RS01885	419171..419398	+	228	WP_071681679.1	sulfurtransferase TusA family protein	-
FD644_RS01890	419594..419830	+	237	WP_021181593.1	DUF4282 domain-containing protein	-
FD644_RS01895	420164..420637	-	474	WP_071681681.1	hypothetical protein	-
FD644_RS01900	420621..421451	-	831	WP_071681683.1	winged helix-turn-helix domain-containing protein	-
FD644_RS01905	422128..422526	+	399	WP_071681685.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	417145..428649	11504

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (43-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-92)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17698.56 Da
• Isoelectric Point: 9.6140

>T125055 WP_059199146.1 NZ_CP040182:c417627-417145 [Serratia fonticola]
MGMKAPEPLSSGHNLADFCSSEPMLNEWLRKKALKNHSAGISRVYVICAEETHRVIGYYCLATGSVQRNTAPGAYRRNAP
ESLPVIVLGRLAIDQAYSGKGLGVALLKDAIFRTNNIAQQVGVRALIVHALNEEVRNFYIKFAFSPSPEHPLMLFYPIKL

Nucleotide

• Length: 483 bp

>T125055 NZ_CP040182:c417627-417145 [Serratia fonticola]
ATGGGAATGAAAGCTCCCGAGCCCTTGTCATCCGGGCATAACCTCGCTGACTTTTGCAGTTCAGAGCCGATGCTTAATGA
GTGGCTGAGAAAGAAAGCGCTTAAAAATCATAGCGCAGGAATTTCCCGCGTTTATGTTATTTGCGCAGAGGAAACCCATA
GGGTCATTGGATACTATTGCCTAGCAACGGGTAGCGTTCAGAGGAATACCGCCCCCGGAGCTTACAGACGCAATGCGCCA
GAGTCACTTCCAGTTATCGTTCTTGGCAGACTTGCTATCGATCAGGCGTACTCAGGTAAGGGTCTGGGGGTCGCATTGTT
AAAAGACGCGATATTTCGGACAAATAATATTGCTCAACAAGTTGGCGTGAGAGCGTTAATTGTTCATGCATTGAATGAAG
AGGTGCGAAACTTCTACATCAAGTTCGCCTTCTCCCCCTCCCCTGAACACCCACTGATGCTGTTTTATCCAATAAAGCTT
TAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10641.12 Da
• Isoelectric Point: 4.4247

>AT125055 WP_059199145.1 NZ_CP040182:c417896-417618 [Serratia fonticola]
MKPETREAPINIRAKASQRDLIDMAASLLSKSRTDFMLEVACREAQDILLDQRLFILDDEQYDAFLTELDAPITAERQAR
INDLMSRKSPWE

Nucleotide

• Length: 279 bp

>AT125055 NZ_CP040182:c417896-417618 [Serratia fonticola]
ATGAAACCTGAAACTAGAGAAGCCCCGATCAATATTCGGGCAAAAGCGTCTCAACGCGACCTGATCGATATGGCTGCAAG
TCTCTTGTCGAAATCGCGTACCGATTTCATGCTTGAAGTGGCTTGCCGCGAGGCGCAGGACATCCTACTGGACCAGCGTT
TGTTTATCTTAGACGACGAACAGTATGATGCGTTTCTGACCGAACTGGATGCGCCTATCACCGCTGAACGCCAGGCCCGT
ATTAACGACCTGATGAGCCGCAAATCGCCATGGGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3G2FKC3