Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 42005..42648 Replicon plasmid unnamed1
Accession NZ_CP040167
Organism Piscirickettsia salmonis strain Psal-104b

Toxin (Protein)


Gene name vapC Uniprot ID A0A1L6TI66
Locus tag Psal104b_RS16440 Protein ID WP_027242931.1
Coordinates 42005..42412 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L6TI10
Locus tag Psal104b_RS16445 Protein ID WP_027242932.1
Coordinates 42421..42648 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal104b_RS16415 (Psal104b_03261) 37602..38933 - 1332 WP_048876205.1 terminase large subunit -
Psal104b_RS16420 (Psal104b_03262) 38936..39418 - 483 WP_075278733.1 P27 family phage terminase small subunit -
Psal104b_RS16425 (Psal104b_03263) 39505..39888 - 384 WP_027242929.1 HNH endonuclease -
Psal104b_RS16430 (Psal104b_03264) 40084..40287 - 204 WP_017375952.1 hypothetical protein -
Psal104b_RS16435 (Psal104b_03265) 40477..41859 - 1383 WP_027242930.1 hypothetical protein -
Psal104b_RS16440 (Psal104b_03266) 42005..42412 - 408 WP_027242931.1 type II toxin-antitoxin system VapC family toxin Toxin
Psal104b_RS16445 (Psal104b_03267) 42421..42648 - 228 WP_027242932.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Psal104b_RS16450 (Psal104b_03268) 42781..43173 - 393 WP_017375958.1 hypothetical protein -
Psal104b_RS18290 43494..43616 + 123 WP_257721321.1 hypothetical protein -
Psal104b_RS16455 (Psal104b_03269) 44025..44354 - 330 WP_162038692.1 HigA family addiction module antitoxin -
Psal104b_RS16460 44420..44569 + 150 WP_196214251.1 hypothetical protein -
Psal104b_RS16465 (Psal104b_03270) 44707..44940 - 234 WP_017375959.1 type II toxin-antitoxin system RelE/ParE family toxin -
Psal104b_RS16470 (Psal104b_03271) 45242..46285 + 1044 WP_017375960.1 NAD(P)-dependent alcohol dehydrogenase -
Psal104b_RS16475 (Psal104b_03272) 46393..46800 + 408 WP_036817201.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..169619 169619


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(7-41)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15562.93 Da        Isoelectric Point: 7.4168

>T125029 WP_027242931.1 NZ_CP040167:c42412-42005 [Piscirickettsia salmonis]
MLYMLDTNICIYLIKQKPRSYYERLMEVEKSRHILAISSIVLSELQFGVARSQHQRKNQEAINTLVNKLDVLPYEEKAAK
YYGDLRADLQKKGTVIGGNDMIIAAHALSEKAVLVTHNTKEFQRVDHLELEDWAS

Download         Length: 408 bp

>T125029 NZ_CP040167:c42412-42005 [Piscirickettsia salmonis]
ATGCTTTATATGCTGGATACGAATATTTGTATTTATTTAATTAAACAAAAACCTCGCTCTTACTATGAGCGTTTGATGGA
GGTAGAAAAATCTCGTCATATATTGGCGATTTCATCGATTGTTTTATCTGAATTACAGTTTGGAGTGGCTCGCAGTCAAC
ACCAGCGAAAAAATCAGGAAGCAATTAATACCTTGGTGAATAAGCTCGATGTTTTACCCTATGAGGAAAAGGCAGCTAAA
TACTATGGTGACTTAAGGGCTGACTTACAAAAAAAAGGGACTGTGATTGGTGGGAATGATATGATCATAGCCGCACATGC
GCTTTCAGAAAAGGCTGTTTTAGTAACGCATAATACAAAAGAGTTTCAGCGTGTCGATCATTTAGAGCTTGAAGACTGGG
CAAGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8948.07 Da        Isoelectric Point: 4.5700

>AT125029 WP_027242932.1 NZ_CP040167:c42648-42421 [Piscirickettsia salmonis]
MAKSRIFKSGNSQAVRLPKEMRLDGEEVVIHRFGNSLLIQPVYETWMDVYNHMPDVSDDFMEDRQDIQAQERDWF

Download         Length: 228 bp

>AT125029 NZ_CP040167:c42648-42421 [Piscirickettsia salmonis]
ATGGCAAAATCACGAATTTTTAAAAGTGGTAATTCTCAAGCCGTTCGATTACCGAAAGAAATGCGCCTTGATGGTGAAGA
AGTGGTTATTCATCGGTTTGGCAACTCTTTATTAATCCAGCCAGTTTATGAAACCTGGATGGATGTTTACAATCATATGC
CGGATGTATCGGATGATTTTATGGAGGATCGCCAAGATATACAAGCACAAGAACGTGACTGGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6TI66

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI10

References