Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 21953..22484 Replicon plasmid unnamed1
Accession NZ_CP040167
Organism Piscirickettsia salmonis strain Psal-104b

Toxin (Protein)


Gene name relE Uniprot ID A0A7U4YYE1
Locus tag Psal104b_RS16315 Protein ID WP_027243212.1
Coordinates 21953..22240 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1L6TI86
Locus tag Psal104b_RS16320 Protein ID WP_027243211.1
Coordinates 22230..22484 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal104b_RS16285 (Psal104b_03238) 17328..18056 + 729 WP_036771359.1 IS6-like element ISPsa2 family transposase -
Psal104b_RS16290 (Psal104b_03239) 18184..19161 - 978 WP_036771347.1 IS5 family transposase -
Psal104b_RS16295 (Psal104b_03240) 19288..19542 + 255 WP_247025513.1 DUF1561 family protein -
Psal104b_RS16300 (Psal104b_03241) 19650..20627 + 978 WP_036771347.1 IS5 family transposase -
Psal104b_RS16305 (Psal104b_03242) 20631..21458 + 828 WP_069971703.1 IS5 family transposase -
Psal104b_RS16310 (Psal104b_03243) 21473..21946 + 474 WP_230382695.1 tail assembly protein -
Psal104b_RS16315 (Psal104b_03244) 21953..22240 - 288 WP_027243212.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Psal104b_RS16320 (Psal104b_03245) 22230..22484 - 255 WP_027243211.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Psal104b_RS16325 22702..22863 - 162 WP_155046636.1 hypothetical protein -
Psal104b_RS16330 (Psal104b_03246) 22878..23855 - 978 WP_036771347.1 IS5 family transposase -
Psal104b_RS16335 23874..24107 - 234 WP_062365770.1 hypothetical protein -
Psal104b_RS16340 (Psal104b_03247) 24189..25166 + 978 WP_036771347.1 IS5 family transposase -
Psal104b_RS16345 (Psal104b_03248) 25206..25550 + 345 Protein_34 DDE-type integrase/transposase/recombinase -
Psal104b_RS16350 (Psal104b_03249) 25632..26612 - 981 WP_144420849.1 hypothetical protein -
Psal104b_RS16355 (Psal104b_03250) 26844..27353 - 510 WP_027242595.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..169619 169619


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-55)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11063.21 Da        Isoelectric Point: 10.8855

>T125028 WP_027243212.1 NZ_CP040167:c22240-21953 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLAIG
SRNRLEAYRLAASRL

Download         Length: 288 bp

>T125028 NZ_CP040167:c22240-21953 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9554.83 Da        Isoelectric Point: 4.3176

>AT125028 WP_027243211.1 NZ_CP040167:c22484-22230 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Download         Length: 255 bp

>AT125028 NZ_CP040167:c22484-22230 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4YYE1

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI86

References