Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2668278..2669041 Replicon chromosome
Accession NZ_CP040166
Organism Piscirickettsia salmonis strain Psal-104b

Toxin (Protein)


Gene name ataT Uniprot ID A0A1L6TH26
Locus tag Psal104b_RS13590 Protein ID WP_017376502.1
Coordinates 2668278..2668787 (-) Length 170 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A1L6TGZ1
Locus tag Psal104b_RS13595 Protein ID WP_017376501.1
Coordinates 2668775..2669041 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal104b_RS13560 (Psal104b_02687) 2663290..2664405 + 1116 WP_017376001.1 DSD1 family PLP-dependent enzyme -
Psal104b_RS13565 (Psal104b_02688) 2664565..2665092 + 528 WP_026063500.1 inorganic diphosphatase -
Psal104b_RS13570 (Psal104b_02689) 2665092..2665622 + 531 WP_017375999.1 transcriptional repressor -
Psal104b_RS13575 (Psal104b_02691) 2666201..2667088 + 888 Protein_2693 transposase -
Psal104b_RS13585 (Psal104b_02692) 2667282..2668157 + 876 WP_048875904.1 IS982 family transposase -
Psal104b_RS13590 (Psal104b_02693) 2668278..2668787 - 510 WP_017376502.1 GNAT family N-acetyltransferase Toxin
Psal104b_RS13595 (Psal104b_02694) 2668775..2669041 - 267 WP_017376501.1 DUF1778 domain-containing protein Antitoxin
Psal104b_RS13600 (Psal104b_02695) 2669207..2670181 - 975 WP_048875903.1 IS30 family transposase -
Psal104b_RS13605 (Psal104b_02696) 2670361..2670981 - 621 WP_075275269.1 transposase -
Psal104b_RS13610 (Psal104b_02697) 2670978..2671274 - 297 Protein_2699 transposase -
Psal104b_RS13615 (Psal104b_02698) 2671288..2672691 - 1404 WP_048876031.1 IS4 family transposase -
Psal104b_RS13620 (Psal104b_02699) 2672815..2673402 - 588 Protein_2701 IS982-like element ISPsa1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 2667282..2673402 6120


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(70-146)

Antitoxin

Vibrio phage ICP1, Orf50

(7-81)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 18875.95 Da        Isoelectric Point: 8.6859

>T125027 WP_017376502.1 NZ_CP040166:c2668787-2668278 [Piscirickettsia salmonis]
MGEITPPELLESSHDTRGFDCGDIALNEWLQKRGLKNQTSDASRVYVITNRHRVIGYYALASGSVERMIVPGSIARNMPE
TIPVIVLGRLAVDLDYHDQKLGSGLLKDALIRCMLAADTIAAKAVMVHAISDRAKQFYTKNSFVQCPEIEMTLFISIKKI
RQLLKNETK

Download         Length: 510 bp

>T125027 NZ_CP040166:c2668787-2668278 [Piscirickettsia salmonis]
TTGGGAGAAATAACACCGCCGGAGCTGCTAGAGTCTAGCCATGATACTCGAGGTTTTGATTGCGGAGATATTGCGCTTAA
TGAGTGGTTACAAAAGCGAGGATTAAAAAATCAGACCTCTGATGCAAGTCGAGTGTATGTAATTACTAATCGTCATCGAG
TGATTGGCTATTATGCGTTAGCCAGTGGCTCTGTGGAGCGAATGATCGTACCTGGCTCCATAGCTCGTAATATGCCAGAG
ACAATTCCGGTGATTGTGCTAGGGCGGCTAGCCGTTGACCTTGATTATCACGATCAAAAACTAGGAAGCGGCTTATTAAA
AGATGCTTTAATTCGGTGTATGCTAGCTGCTGATACAATCGCTGCAAAGGCAGTCATGGTTCATGCAATCTCAGATAGAG
CAAAACAGTTTTATACTAAAAACTCTTTTGTCCAATGTCCTGAAATTGAAATGACTTTATTTATTTCTATAAAAAAAATT
AGGCAACTTCTAAAAAATGAAACAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10033.51 Da        Isoelectric Point: 4.4819

>AT125027 WP_017376501.1 NZ_CP040166:c2669041-2668775 [Piscirickettsia salmonis]
MAKVTPISMRTTAEQFDLLTKAANALNIDRTSFILNIACREAENVLLDRRLFQLNDEAFDAFEAALDEPLTQPEKLKRLL
TEPAPWEK

Download         Length: 267 bp

>AT125027 NZ_CP040166:c2669041-2668775 [Piscirickettsia salmonis]
ATGGCAAAGGTAACACCGATTAGCATGCGTACAACAGCGGAACAGTTTGATTTACTTACTAAAGCAGCAAATGCATTAAA
TATAGACCGCACATCGTTCATTTTGAATATTGCTTGCCGTGAAGCTGAAAACGTACTGCTAGACCGCCGTTTGTTTCAAT
TAAATGATGAAGCTTTTGATGCCTTTGAGGCAGCACTAGATGAGCCATTAACTCAACCAGAGAAATTAAAACGCTTACTA
ACGGAGCCTGCACCTTGGGAGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6TH26

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TGZ1

References