125019

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 149029..149534 Replicon chromosome
Accession NZ_CP040127
Organism Pseudomonas aeruginosa strain PA298

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag E6P00_RS03065 Protein ID WP_003083773.1
Coordinates 149029..149310 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag E6P00_RS03070 Protein ID WP_003083775.1
Coordinates 149307..149534 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E6P00_RS03040 144280..145629 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
E6P00_RS03045 145678..146364 + 687 WP_003083762.1 FadR family transcriptional regulator -
E6P00_RS03050 146465..147199 + 735 WP_003117208.1 GntR family transcriptional regulator -
E6P00_RS03055 147403..147789 + 387 WP_014602345.1 aegerolysin family protein -
E6P00_RS03060 147821..148729 - 909 WP_003083769.1 LysR family transcriptional regulator -
E6P00_RS03065 149029..149310 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
E6P00_RS03070 149307..149534 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
E6P00_RS03075 149710..150330 - 621 WP_009314940.1 hypothetical protein -
E6P00_RS03080 150431..150931 + 501 WP_003112629.1 LEA type 2 family protein -
E6P00_RS03085 151004..151345 + 342 WP_003101229.1 alkylphosphonate utilization protein -
E6P00_RS03090 151427..152854 - 1428 WP_003083784.1 GABA permease -
E6P00_RS03095 153023..154516 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T125019 WP_003083773.1 NZ_CP040127:c149310-149029 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T125019 NZ_CP040127:c149310-149029 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT125019 WP_003083775.1 NZ_CP040127:c149534-149307 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT125019 NZ_CP040127:c149534-149307 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References