Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3572576..3573054 Replicon chromosome
Accession NZ_CP040107
Organism Escherichia coli O157:H7 strain MB9-1

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag FDZ86_RS18405 Protein ID WP_001303876.1
Coordinates 3572767..3573054 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag FDZ86_RS18400 Protein ID WP_000536233.1
Coordinates 3572576..3572767 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDZ86_RS18365 3567980..3568750 - 771 WP_000450992.1 DUF1627 domain-containing protein -
FDZ86_RS18370 3568772..3569518 - 747 WP_000788751.1 ATP-binding protein -
FDZ86_RS18375 3569525..3570616 - 1092 WP_001205823.1 hypothetical protein -
FDZ86_RS18380 3570695..3571150 + 456 WP_000273724.1 hypothetical protein -
FDZ86_RS18385 3571357..3571782 - 426 WP_000693855.1 Rha family transcriptional regulator -
FDZ86_RS18390 3571766..3572038 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
FDZ86_RS18395 3572147..3572548 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
FDZ86_RS18400 3572576..3572767 + 192 WP_000536233.1 hypothetical protein Antitoxin
FDZ86_RS18405 3572767..3573054 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FDZ86_RS18410 3573332..3573487 + 156 WP_000379575.1 DUF1391 family protein -
FDZ86_RS18415 3573629..3574018 + 390 WP_000394511.1 hypothetical protein -
FDZ86_RS18420 3574205..3574390 - 186 WP_001133046.1 hypothetical protein -
FDZ86_RS18425 3574964..3575152 + 189 WP_000413705.1 cell division inhibition protein DicB -
FDZ86_RS18430 3575149..3575340 + 192 WP_001098307.1 DUF1482 family protein -
FDZ86_RS18435 3575434..3577905 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T124977 WP_001303876.1 NZ_CP040107:3572767-3573054 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T124977 NZ_CP040107:3572767-3573054 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT124977 WP_000536233.1 NZ_CP040107:3572576-3572767 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT124977 NZ_CP040107:3572576-3572767 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References