Detailed information of TA system TA124953

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 2488600..2489253
• Replicon: chromosome
• Accession: NZ_CP040105
• Organism: Acinetobacter nosocomialis M2

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: FDQ49_RS11795
• Protein ID: WP_022575951.1
• Coordinates: 2488864..2489253 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N8SCE2
• Locus tag: FDQ49_RS11790
• Protein ID: WP_002049719.1
• Coordinates: 2488600..2488857 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDQ49_RS11770	2484114..2485121	+	1008	WP_002049752.1	DNA-directed RNA polymerase subunit alpha	-
FDQ49_RS11775	2485140..2485517	+	378	WP_002049717.1	50S ribosomal protein L17	-
FDQ49_RS11780	2485699..2487189	+	1491	WP_022575952.1	NAD(P)/FAD-dependent oxidoreductase	-
FDQ49_RS11785	2487238..2488410	-	1173	WP_002049748.1	acyl-CoA dehydrogenase family protein	-
FDQ49_RS11790	2488600..2488857	+	258	WP_002049719.1	succinate dehydrogenase assembly factor 2	Antitoxin
FDQ49_RS11795	2488864..2489253	+	390	WP_022575951.1	hypothetical protein	Toxin
FDQ49_RS11800	2490021..2491106	+	1086	WP_002049690.1	hypothetical protein	-
FDQ49_RS11805	2491190..2491756	+	567	WP_004711824.1	rhombosortase	-
FDQ49_RS11810	2491944..2494139	+	2196	WP_006580689.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15637.74 Da
• Isoelectric Point: 10.2623

>T124953 WP_022575951.1 NZ_CP040105:2488864-2489253 [Acinetobacter nosocomialis M2]
MVNHLNFKLKYSRFAIIFQFFIGLSLVVLFYQLLPILWWLVTVSLLFISFIFFLKRPQLAQIAHLDQKLWSLSFHSEQTI
SRVEILKIINYQIFIVIYFEGHKTLTSVIWFDQMPLSQWKQLKTLEKFY

Nucleotide

• Length: 390 bp

>T124953 NZ_CP040105:2488864-2489253 [Acinetobacter nosocomialis M2]
TTGGTCAACCATTTGAATTTCAAACTGAAATATAGCCGTTTTGCGATTATATTTCAGTTTTTTATTGGCTTAAGTTTGGT
AGTTCTATTTTATCAACTCCTACCAATATTATGGTGGTTGGTTACGGTCAGTTTACTATTCATAAGTTTTATTTTCTTTT
TAAAGCGGCCACAGCTCGCTCAAATTGCTCATTTAGATCAAAAATTATGGTCACTTAGCTTTCATTCAGAACAAACAATT
TCTCGGGTAGAGATTTTAAAAATAATTAATTATCAGATTTTCATAGTGATCTATTTTGAAGGGCATAAGACACTAACTTC
TGTTATTTGGTTTGATCAAATGCCTTTATCTCAGTGGAAACAACTTAAAACTTTAGAAAAATTTTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10278.71 Da
• Isoelectric Point: 4.7620

>AT124953 WP_002049719.1 NZ_CP040105:2488600-2488857 [Acinetobacter nosocomialis M2]
MSEEMTLEERKVVYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIHKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT124953 NZ_CP040105:2488600-2488857 [Acinetobacter nosocomialis M2]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTT
TGACCCGTATGTGAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTATTTGCTGAATTAGTAGAGCAGGAAG
ATCCTGATTTACTTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAG
CATTATGTTCATGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0Q1QI86