Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 2211170..2211729 | Replicon | chromosome |
| Accession | NZ_CP040103 | ||
| Organism | Vibrio parahaemolyticus strain LVP66 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A2K7SRU8 |
| Locus tag | FDV79_RS10525 | Protein ID | WP_017035198.1 |
| Coordinates | 2211451..2211729 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR21 |
| Locus tag | FDV79_RS10520 | Protein ID | WP_005398409.1 |
| Coordinates | 2211170..2211454 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FDV79_RS10470 | 2206243..2206800 | - | 558 | WP_140101544.1 | hypothetical protein | - |
| FDV79_RS10475 | 2206950..2207912 | - | 963 | WP_140381327.1 | hypothetical protein | - |
| FDV79_RS10480 | 2207951..2208061 | - | 111 | WP_178978985.1 | DUF3265 domain-containing protein | - |
| FDV79_RS10485 | 2208058..2208513 | - | 456 | WP_062858332.1 | hypothetical protein | - |
| FDV79_RS10490 | 2208659..2208985 | - | 327 | WP_140381328.1 | hypothetical protein | - |
| FDV79_RS10495 | 2209013..2209144 | - | 132 | WP_080765387.1 | DUF3265 domain-containing protein | - |
| FDV79_RS10500 | 2209120..2209767 | - | 648 | WP_045397020.1 | hypothetical protein | - |
| FDV79_RS10505 | 2209815..2209907 | - | 93 | Protein_2008 | DUF3265 domain-containing protein | - |
| FDV79_RS10510 | 2210347..2210457 | - | 111 | WP_114322036.1 | DUF3265 domain-containing protein | - |
| FDV79_RS10515 | 2210986..2211093 | - | 108 | WP_140381332.1 | DUF3265 domain-containing protein | - |
| FDV79_RS10520 | 2211170..2211454 | + | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| FDV79_RS10525 | 2211451..2211729 | + | 279 | WP_017035198.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| FDV79_RS10530 | 2211758..2211874 | - | 117 | WP_178978986.1 | DUF3265 domain-containing protein | - |
| FDV79_RS10535 | 2211871..2212296 | - | 426 | WP_140381334.1 | hypothetical protein | - |
| FDV79_RS10540 | 2212346..2213197 | - | 852 | WP_178978928.1 | IS3 family transposase | - |
| FDV79_RS10545 | 2213281..2213502 | - | 222 | Protein_2016 | transposase | - |
| FDV79_RS10550 | 2213713..2214336 | - | 624 | WP_130350007.1 | hypothetical protein | - |
| FDV79_RS10555 | 2214397..2214507 | - | 111 | WP_080586398.1 | DUF3265 domain-containing protein | - |
| FDV79_RS10560 | 2214504..2215013 | - | 510 | WP_045419680.1 | hypothetical protein | - |
| FDV79_RS10565 | 2215023..2215193 | - | 171 | WP_080640432.1 | DUF3265 domain-containing protein | - |
| FDV79_RS10570 | 2215130..2215705 | - | 576 | WP_140381374.1 | hypothetical protein | - |
| FDV79_RS10575 | 2215842..2216216 | - | 375 | WP_025441761.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2118607..2254619 | 136012 | |
| - | inside | Integron | - | - | 2158049..2252908 | 94859 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10905.60 Da Isoelectric Point: 4.3430
>T124952 WP_017035198.1 NZ_CP040103:2211451-2211729 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWIEGDIIRVM
RVLHQKQKFPTD
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWIEGDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T124952 NZ_CP040103:2211451-2211729 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTGCAACGAGATGGCA
TCCGCGGACGATTACTCATCATTCCTGAGATTTCGATGATTGTCTCTTACTGGATTGAGGGCGATATCATCCGAGTTATG
CGTGTACTACACCAGAAACAAAAATTCCCTACGGATTGA
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTGCAACGAGATGGCA
TCCGCGGACGATTACTCATCATTCCTGAGATTTCGATGATTGTCTCTTACTGGATTGAGGGCGATATCATCCGAGTTATG
CGTGTACTACACCAGAAACAAAAATTCCCTACGGATTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11069.40 Da Isoelectric Point: 9.2167
>AT124952 WP_005398409.1 NZ_CP040103:2211170-2211454 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT124952 NZ_CP040103:2211170-2211454 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGAGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCGTTGAGCACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGAGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCGTTGAGCACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2K7SRU8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR21 |