Detailed information of TA system TA124951

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1662770..1663329
• Replicon: chromosome
• Accession: NZ_CP040101
• Organism: Vibrio parahaemolyticus strain LVP2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A347UR22
• Locus tag: FDV78_RS07925
• Protein ID: WP_005398411.1
• Coordinates: 1662770..1663048 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FDV78_RS07930
• Protein ID: WP_179000643.1
• Coordinates: 1663045..1663329 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDV78_RS07875	1658243..1658833	+	591	WP_179000637.1	hypothetical protein	-
FDV78_RS07880	1658830..1658946	+	117	WP_179001302.1	DUF3265 domain-containing protein	-
FDV78_RS07885	1658915..1659319	+	405	WP_179000638.1	hypothetical protein	-
FDV78_RS07890	1659484..1659873	+	390	WP_179000639.1	hypothetical protein	-
FDV78_RS07895	1660341..1660463	+	123	WP_179001304.1	DUF3265 domain-containing protein	-
FDV78_RS07900	1660922..1660999	+	78	WP_179001306.1	DUF3265 domain-containing protein	-
FDV78_RS07905	1661036..1661899	+	864	WP_179000640.1	hypothetical protein	-
FDV78_RS07910	1661904..1662005	+	102	WP_079766270.1	DUF3265 domain-containing protein	-
FDV78_RS07915	1662044..1662628	+	585	WP_179000641.1	hypothetical protein	-
FDV78_RS07920	1662622..1662741	+	120	WP_179000642.1	DUF3265 domain-containing protein	-
FDV78_RS07925	1662770..1663048	-	279	WP_005398411.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
FDV78_RS07930	1663045..1663329	-	285	WP_179000643.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FDV78_RS07935	1663857..1663979	+	123	WP_179001310.1	DUF3265 domain-containing protein	-
FDV78_RS07940	1663996..1664469	+	474	WP_179000644.1	hypothetical protein	-
FDV78_RS07945	1664498..1664575	+	78	WP_179001308.1	DUF3265 domain-containing protein	-
FDV78_RS07950	1664602..1665024	+	423	WP_179000645.1	hypothetical protein	-
FDV78_RS07955	1665521..1665682	+	162	WP_179000646.1	DUF3265 domain-containing protein	-
FDV78_RS07960	1666152..1666230	+	79	Protein_1478	DUF3265 domain-containing protein	-
FDV78_RS07965	1666269..1667006	+	738	WP_155761234.1	HNH endonuclease	-
FDV78_RS07970	1667156..1667917	+	762	WP_140310064.1	hypothetical protein	-
FDV78_RS07975	1667881..1668036	+	156	WP_164842003.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	vpadF	1527663..1811736	284073
	-	inside	Integron	-	-	1632625..1715656	83031

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10891.57 Da
• Isoelectric Point: 4.3430

>T124951 WP_005398411.1 NZ_CP040101:c1663048-1662770 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T124951 NZ_CP040101:c1663048-1662770 [Vibrio parahaemolyticus]
ATGATTTTGTGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
TGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAGCAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTACTTCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11046.35 Da
• Isoelectric Point: 9.2191

>AT124951 WP_179000643.1 NZ_CP040101:c1663329-1663045 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVDHHTAKSR
IEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT124951 NZ_CP040101:c1663329-1663045 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TTTGAGTGACGCATGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGACCACCACACTGCTAAATCTCGA
ATAGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Structures

Toxin

• AlphaFold DB: A0A347UR22