Detailed information of TA system TA124950

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2382977..2384538
• Replicon: chromosome
• Accession: NZ_CP040100
• Organism: Vibrio parahaemolyticus strain LVP1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: FDP11_RS19965
• Protein ID: WP_130546572.1
• Coordinates: 2382977..2384305 (-)
• Length: 443 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: FDP11_RS19970
• Protein ID: WP_017788886.1
• Coordinates: 2384299..2384538 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDP11_RS19940	2378062..2378526	+	465	WP_178982667.1	hotdog family protein	-
FDP11_RS19945	2378523..2379248	+	726	WP_015296414.1	3-oxoacyl-ACP reductase FabG	-
FDP11_RS19950	2379245..2380468	+	1224	WP_021452981.1	beta-ketoacyl-ACP synthase	-
FDP11_RS19955	2380514..2381104	-	591	WP_023624128.1	membrane lipoprotein lipid attachment site-containing protein	-
FDP11_RS19960	2381458..2382783	+	1326	WP_178982669.1	site-specific integrase	-
FDP11_RS19965	2382977..2384305	-	1329	WP_130546572.1	type II toxin-antitoxin system HipA family toxin	Toxin
FDP11_RS19970	2384299..2384538	-	240	WP_017788886.1	helix-turn-helix domain-containing protein	Antitoxin
FDP11_RS19975	2385131..2386939	+	1809	WP_011079937.1	ATP-binding protein	-
FDP11_RS19980	2386948..2388255	+	1308	WP_178982671.1	HNH endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2381458..2408701	27243

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (151-400)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-55)

Sequences

Toxin

Protein

• Length: 443 a.a.
• Molecular weight: 49461.75 Da
• Isoelectric Point: 8.8663

>T124950 WP_130546572.1 NZ_CP040100:c2384305-2382977 [Vibrio parahaemolyticus]
MVNRLHAYMNGVKVGVLEKRTNGAHVFTYDSDWISAPNGRPISLSMPLRKDAYTGSEVINFFDNLLPDNQQIRNRIAARY
KADTKQPFDLLAKVGRDAVGAITLVPEGFDVDDHRVITAKALSDKELVRILKGYMEGAPLGMLKEEDDFRISIAGAQEKT
ALLFHDGRWMLPQGMTPTTHIIKLPIGEIVSQNNVIDLSASVDNELICMRLAKAFGIQTANCGIIQAGDVRALSVERFDR
KLSADNGYYLRLPHEDFCQAKGIPSARKYESDGGIGIEEAVDILRYSYEINDTVTFARSQILFWLLAAIDGHGKNFSVSI
AASGRYQLAPLYDIISAHPLTGGRGLSERKIKMAMSLRGTSGRKWKWHQLQPRHFEDTFHTMNVPNIRREKVRLLLDEFE
STAMEVIDSVGNSLPTDINESVRDKIFNGVLKTVKKIQLTKK

Nucleotide

• Length: 1329 bp

>T124950 NZ_CP040100:c2384305-2382977 [Vibrio parahaemolyticus]
ATGGTGAATCGACTTCATGCTTACATGAATGGCGTAAAGGTTGGGGTACTTGAAAAGCGCACAAACGGCGCACATGTTTT
CACTTACGATTCGGACTGGATTTCAGCACCAAATGGTCGTCCTATCTCGCTTTCTATGCCTCTCAGGAAGGATGCGTATA
CTGGCAGTGAGGTTATTAACTTCTTTGATAACTTACTGCCAGATAACCAGCAGATACGAAATAGAATAGCTGCTCGCTAT
AAAGCAGATACTAAACAGCCCTTTGACCTATTAGCTAAGGTTGGTCGAGATGCTGTAGGTGCTATCACGTTAGTTCCAGA
AGGCTTTGATGTAGATGATCATCGAGTTATAACCGCAAAGGCGTTATCCGACAAGGAATTGGTTAGAATCCTAAAGGGAT
ATATGGAGGGCGCTCCTCTGGGGATGCTGAAAGAGGAAGATGATTTTAGGATCTCGATAGCGGGAGCGCAGGAAAAGACA
GCCTTACTATTCCACGATGGAAGATGGATGTTGCCACAGGGAATGACTCCAACTACGCATATTATCAAGCTGCCAATAGG
TGAAATTGTTTCTCAGAACAATGTTATTGATTTGTCTGCAAGTGTCGATAATGAGTTGATTTGTATGAGACTAGCAAAGG
CGTTCGGCATTCAAACGGCAAACTGTGGCATTATTCAAGCTGGTGATGTTCGTGCTTTGTCTGTTGAGCGATTTGATAGA
AAGTTATCTGCTGATAATGGCTATTACTTGCGCTTGCCTCATGAGGACTTTTGCCAGGCAAAAGGGATTCCATCGGCTAG
AAAATATGAAAGCGATGGTGGTATCGGTATAGAAGAAGCTGTTGATATTTTGCGATACTCATACGAAATCAACGATACCG
TTACTTTTGCACGTTCTCAGATATTGTTTTGGCTACTAGCTGCCATTGACGGGCATGGAAAGAATTTCTCTGTAAGTATA
GCCGCATCTGGTCGATATCAGCTTGCACCACTGTATGACATTATTTCGGCACATCCACTGACAGGTGGGCGTGGTTTGAG
TGAGCGTAAGATCAAGATGGCAATGAGCTTACGTGGCACTAGTGGTCGAAAATGGAAGTGGCACCAACTTCAACCGCGCC
ATTTCGAAGATACCTTTCACACTATGAACGTCCCGAACATAAGGCGAGAAAAGGTTCGCTTATTGCTCGACGAGTTTGAA
TCGACGGCAATGGAGGTGATTGATTCTGTCGGAAACTCGCTACCAACTGATATCAATGAAAGCGTAAGAGATAAGATATT
TAACGGTGTCTTAAAGACCGTCAAGAAGATTCAATTGACAAAAAAATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8717.96 Da
• Isoelectric Point: 7.2036

>AT124950 WP_017788886.1 NZ_CP040100:c2384538-2384299 [Vibrio parahaemolyticus]
MLVNTPTALGNALREARKDNGLKQTDLGLRQATVSNFESNPEKSTIETLFKLLSINGLEMHIVPKGKHITETKGAVDEW

Nucleotide

• Length: 240 bp

>AT124950 NZ_CP040100:c2384538-2384299 [Vibrio parahaemolyticus]
ATGCTAGTTAACACACCGACAGCCCTCGGCAATGCGTTACGCGAAGCCCGAAAGGACAACGGCCTAAAGCAAACAGATCT
TGGCCTGCGGCAAGCAACGGTATCAAATTTTGAAAGCAACCCTGAAAAATCCACGATAGAAACATTATTCAAGCTCCTGT
CTATCAATGGACTAGAAATGCATATTGTGCCTAAAGGCAAGCACATTACTGAAACTAAAGGGGCTGTTGACGAATGGTGA