Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2382977..2384538 Replicon chromosome
Accession NZ_CP040100
Organism Vibrio parahaemolyticus strain LVP1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FDP11_RS19965 Protein ID WP_130546572.1
Coordinates 2382977..2384305 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FDP11_RS19970 Protein ID WP_017788886.1
Coordinates 2384299..2384538 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDP11_RS19940 2378062..2378526 + 465 WP_178982667.1 hotdog family protein -
FDP11_RS19945 2378523..2379248 + 726 WP_015296414.1 3-oxoacyl-ACP reductase FabG -
FDP11_RS19950 2379245..2380468 + 1224 WP_021452981.1 beta-ketoacyl-ACP synthase -
FDP11_RS19955 2380514..2381104 - 591 WP_023624128.1 membrane lipoprotein lipid attachment site-containing protein -
FDP11_RS19960 2381458..2382783 + 1326 WP_178982669.1 site-specific integrase -
FDP11_RS19965 2382977..2384305 - 1329 WP_130546572.1 type II toxin-antitoxin system HipA family toxin Toxin
FDP11_RS19970 2384299..2384538 - 240 WP_017788886.1 helix-turn-helix domain-containing protein Antitoxin
FDP11_RS19975 2385131..2386939 + 1809 WP_011079937.1 ATP-binding protein -
FDP11_RS19980 2386948..2388255 + 1308 WP_178982671.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2381458..2408701 27243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(151-400)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-55)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 49461.75 Da        Isoelectric Point: 8.8663

>T124950 WP_130546572.1 NZ_CP040100:c2384305-2382977 [Vibrio parahaemolyticus]
MVNRLHAYMNGVKVGVLEKRTNGAHVFTYDSDWISAPNGRPISLSMPLRKDAYTGSEVINFFDNLLPDNQQIRNRIAARY
KADTKQPFDLLAKVGRDAVGAITLVPEGFDVDDHRVITAKALSDKELVRILKGYMEGAPLGMLKEEDDFRISIAGAQEKT
ALLFHDGRWMLPQGMTPTTHIIKLPIGEIVSQNNVIDLSASVDNELICMRLAKAFGIQTANCGIIQAGDVRALSVERFDR
KLSADNGYYLRLPHEDFCQAKGIPSARKYESDGGIGIEEAVDILRYSYEINDTVTFARSQILFWLLAAIDGHGKNFSVSI
AASGRYQLAPLYDIISAHPLTGGRGLSERKIKMAMSLRGTSGRKWKWHQLQPRHFEDTFHTMNVPNIRREKVRLLLDEFE
STAMEVIDSVGNSLPTDINESVRDKIFNGVLKTVKKIQLTKK

Download         Length: 1329 bp

>T124950 NZ_CP040100:c2384305-2382977 [Vibrio parahaemolyticus]
ATGGTGAATCGACTTCATGCTTACATGAATGGCGTAAAGGTTGGGGTACTTGAAAAGCGCACAAACGGCGCACATGTTTT
CACTTACGATTCGGACTGGATTTCAGCACCAAATGGTCGTCCTATCTCGCTTTCTATGCCTCTCAGGAAGGATGCGTATA
CTGGCAGTGAGGTTATTAACTTCTTTGATAACTTACTGCCAGATAACCAGCAGATACGAAATAGAATAGCTGCTCGCTAT
AAAGCAGATACTAAACAGCCCTTTGACCTATTAGCTAAGGTTGGTCGAGATGCTGTAGGTGCTATCACGTTAGTTCCAGA
AGGCTTTGATGTAGATGATCATCGAGTTATAACCGCAAAGGCGTTATCCGACAAGGAATTGGTTAGAATCCTAAAGGGAT
ATATGGAGGGCGCTCCTCTGGGGATGCTGAAAGAGGAAGATGATTTTAGGATCTCGATAGCGGGAGCGCAGGAAAAGACA
GCCTTACTATTCCACGATGGAAGATGGATGTTGCCACAGGGAATGACTCCAACTACGCATATTATCAAGCTGCCAATAGG
TGAAATTGTTTCTCAGAACAATGTTATTGATTTGTCTGCAAGTGTCGATAATGAGTTGATTTGTATGAGACTAGCAAAGG
CGTTCGGCATTCAAACGGCAAACTGTGGCATTATTCAAGCTGGTGATGTTCGTGCTTTGTCTGTTGAGCGATTTGATAGA
AAGTTATCTGCTGATAATGGCTATTACTTGCGCTTGCCTCATGAGGACTTTTGCCAGGCAAAAGGGATTCCATCGGCTAG
AAAATATGAAAGCGATGGTGGTATCGGTATAGAAGAAGCTGTTGATATTTTGCGATACTCATACGAAATCAACGATACCG
TTACTTTTGCACGTTCTCAGATATTGTTTTGGCTACTAGCTGCCATTGACGGGCATGGAAAGAATTTCTCTGTAAGTATA
GCCGCATCTGGTCGATATCAGCTTGCACCACTGTATGACATTATTTCGGCACATCCACTGACAGGTGGGCGTGGTTTGAG
TGAGCGTAAGATCAAGATGGCAATGAGCTTACGTGGCACTAGTGGTCGAAAATGGAAGTGGCACCAACTTCAACCGCGCC
ATTTCGAAGATACCTTTCACACTATGAACGTCCCGAACATAAGGCGAGAAAAGGTTCGCTTATTGCTCGACGAGTTTGAA
TCGACGGCAATGGAGGTGATTGATTCTGTCGGAAACTCGCTACCAACTGATATCAATGAAAGCGTAAGAGATAAGATATT
TAACGGTGTCTTAAAGACCGTCAAGAAGATTCAATTGACAAAAAAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8717.96 Da        Isoelectric Point: 7.2036

>AT124950 WP_017788886.1 NZ_CP040100:c2384538-2384299 [Vibrio parahaemolyticus]
MLVNTPTALGNALREARKDNGLKQTDLGLRQATVSNFESNPEKSTIETLFKLLSINGLEMHIVPKGKHITETKGAVDEW

Download         Length: 240 bp

>AT124950 NZ_CP040100:c2384538-2384299 [Vibrio parahaemolyticus]
ATGCTAGTTAACACACCGACAGCCCTCGGCAATGCGTTACGCGAAGCCCGAAAGGACAACGGCCTAAAGCAAACAGATCT
TGGCCTGCGGCAAGCAACGGTATCAAATTTTGAAAGCAACCCTGAAAAATCCACGATAGAAACATTATTCAAGCTCCTGT
CTATCAATGGACTAGAAATGCATATTGTGCCTAAAGGCAAGCACATTACTGAAACTAAAGGGGCTGTTGACGAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References